27118

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1955746..1956352 Replicon chromosome
Accession NC_017618
Organism Streptococcus suis JS14

Toxin (Protein)


Gene name parE Uniprot ID A0A0Z8ZB64
Locus tag SSUJS14_RS09685 Protein ID WP_012775364.1
Coordinates 1955746..1956075 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID D5AKB4
Locus tag SSUJS14_RS09690 Protein ID WP_012028535.1
Coordinates 1956065..1956352 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSUJS14_RS09655 1951158..1952888 - 1731 WP_012775361.1 membrane protein -
SSUJS14_RS09660 1953253..1954161 - 909 WP_079253084.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
SSUJS14_RS09665 1954145..1954675 - 531 WP_009910909.1 DUF1697 domain-containing protein -
SSUJS14_RS09670 1954689..1954946 - 258 WP_012775363.1 Txe/YoeB family addiction module toxin -
SSUJS14_RS09675 1954948..1955208 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
SSUJS14_RS09680 1955284..1955739 - 456 WP_012028534.1 8-oxo-dGTP diphosphatase -
SSUJS14_RS09685 1955746..1956075 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SSUJS14_RS09690 1956065..1956352 - 288 WP_012028535.1 hypothetical protein Antitoxin
SSUJS14_RS09695 1956450..1956818 - 369 WP_012775453.1 hypothetical protein -
SSUJS14_RS09700 1956811..1957380 - 570 WP_012775366.1 ribonuclease M5 -
SSUJS14_RS09705 1957364..1958146 - 783 WP_012028536.1 TatD family hydrolase -
SSUJS14_RS09710 1958253..1958390 - 138 WP_002939016.1 50S ribosomal protein L34 -
SSUJS14_RS09715 1958558..1959553 - 996 WP_012775367.1 protein jag -
SSUJS14_RS09720 1959573..1960385 - 813 WP_012027897.1 YidC/Oxa1 family membrane protein insertase -
SSUJS14_RS09725 1960369..1960728 - 360 WP_004194560.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1914908..1958146 43238


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-95)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12562.52 Da        Isoelectric Point: 7.1991

>T27118 WP_012775364.1 NC_017618:c1956075-1955746 [Streptococcus suis JS14]
MEFESYSVILAPAVEKELAVIYAYFSEQFSEEIAKRRIGMIVEALESLQIFPERGFNADNRFGKQIDPPHLTRGYVVGKD
YIALYRVVKNEVRVGHLFATKSDYVKLLK

Download         Length: 330 bp

>T27118 NC_017618:c1956075-1955746 [Streptococcus suis JS14]
ATGGAATTTGAGTCTTATTCAGTGATACTTGCTCCAGCAGTGGAGAAGGAATTGGCAGTTATTTACGCCTATTTTTCGGA
ACAGTTCTCAGAAGAAATTGCCAAAAGACGAATTGGGATGATTGTCGAAGCATTAGAGAGTTTGCAAATTTTTCCTGAAC
GTGGTTTTAACGCCGATAACCGTTTTGGTAAGCAGATAGACCCGCCTCATCTAACCCGAGGCTATGTCGTTGGAAAAGAC
TACATCGCCCTCTATCGCGTAGTGAAAAATGAAGTTCGAGTTGGTCATCTTTTTGCGACCAAGAGTGATTATGTGAAGTT
GTTGAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10892.43 Da        Isoelectric Point: 4.3464

>AT27118 WP_012028535.1 NC_017618:c1956352-1956065 [Streptococcus suis JS14]
MITINKDAQVNFKTDSRLLEKAKEVFAMNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GHGISLESVKEKYGI

Download         Length: 288 bp

>AT27118 NC_017618:c1956352-1956065 [Streptococcus suis JS14]
TTGATAACTATAAATAAAGATGCCCAAGTAAATTTTAAAACTGATTCCAGACTTTTAGAAAAAGCCAAGGAAGTATTTGC
TATGAACCAGCTGGATTTGACTGCTGGTTTTAACCTCTTCTTGCAAAATATCGCTGTAAAAAATGAGTTGCCAATTCTGA
CAGAAGAAGAGTTGGAAAGAGAAGAGTTGTTTTTACAGTTACAGAAGGAAATCCAGGAAAACCAACAGGCGATTGAGGCA
GGTCACGGGATCAGCCTAGAAAGTGTCAAAGAGAAGTATGGAATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8ZB64

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9A6F4

References