Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-RelB |
Location | 1879904..1880423 | Replicon | chromosome |
Accession | NZ_CP082199 | ||
Organism | Streptococcus suis strain Transconjugant cFJSM5 |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | A0A2K1SXY6 |
Locus tag | K6970_RS09205 | Protein ID | WP_012775363.1 |
Coordinates | 1879904..1880161 (-) | Length | 86 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | A0A0K2E7Z9 |
Locus tag | K6970_RS09210 | Protein ID | WP_002939010.1 |
Coordinates | 1880163..1880423 (-) | Length | 87 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
K6970_RS09190 (K6970_09190) | 1876373..1878103 | - | 1731 | WP_012775361.1 | membrane protein | - |
K6970_RS09195 (K6970_09195) | 1878468..1879340 | - | 873 | WP_012775362.1 | 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA | - |
K6970_RS09200 (K6970_09200) | 1879360..1879890 | - | 531 | WP_009910909.1 | DUF1697 domain-containing protein | - |
K6970_RS09205 (K6970_09205) | 1879904..1880161 | - | 258 | WP_012775363.1 | Txe/YoeB family addiction module toxin | Toxin |
K6970_RS09210 (K6970_09210) | 1880163..1880423 | - | 261 | WP_002939010.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
K6970_RS09215 (K6970_09215) | 1880499..1880954 | - | 456 | WP_012028534.1 | 8-oxo-dGTP diphosphatase | - |
K6970_RS09220 (K6970_09220) | 1880961..1881290 | - | 330 | WP_012775364.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
K6970_RS09225 (K6970_09225) | 1881280..1881567 | - | 288 | WP_012028535.1 | hypothetical protein | - |
K6970_RS09230 (K6970_09230) | 1881665..1882033 | - | 369 | WP_012775453.1 | hypothetical protein | - |
K6970_RS09235 (K6970_09235) | 1882026..1882595 | - | 570 | WP_012775366.1 | ribonuclease M5 | - |
K6970_RS09240 (K6970_09240) | 1882579..1883361 | - | 783 | WP_012028536.1 | TatD family hydrolase | - |
K6970_RS09245 (K6970_09245) | 1883468..1883605 | - | 138 | WP_002939016.1 | 50S ribosomal protein L34 | - |
K6970_RS09250 (K6970_09250) | 1883773..1884768 | - | 996 | WP_012775367.1 | RNA-binding cell elongation regulator Jag/EloR | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | - | 1840134..1883361 | 43227 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 10346.81 Da Isoelectric Point: 7.2737
>T214286 WP_012775363.1 NZ_CP082199:c1880161-1879904 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIQDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIQDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR
Download Length: 258 bp
>T214286 NZ_CP110018:2868589-2868918 [Escherichia coli]
ATGAACACTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGCCTGTCGCCAGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATCG
ATGCTGGTATCACTCTGGCCGATGCAGTCAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCACAGAGGATTT
TCGTGGCAACAACAGTCTCCATATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA
ATGAACACTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGCCTGTCGCCAGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATCG
ATGCTGGTATCACTCTGGCCGATGCAGTCAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCACAGAGGATTT
TCGTGGCAACAACAGTCTCCATATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9980.36 Da Isoelectric Point: 5.7134
>AT214286 WP_002939010.1 NZ_CP082199:c1880423-1880163 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD
Download Length: 261 bp
>AT214286 NZ_CP110018:2868251-2868568 [Escherichia coli]
ATGAGCAACACCACATGGGGCCTGCAGCGAGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCAGCT
GCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTTAGTGACGCCGAATGTCCTAAGCTGGATGTGGTATTTCCAC
ATTTTATCAGCCAGATAGAGTCGATGCTGACCACTGGTGAACTGAATCCCCGCCATGCCCAATGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATACATCGCTGTTTACCCCACTCAACGCTAA
ATGAGCAACACCACATGGGGCCTGCAGCGAGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCAGCT
GCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTTAGTGACGCCGAATGTCCTAAGCTGGATGTGGTATTTCCAC
ATTTTATCAGCCAGATAGAGTCGATGCTGACCACTGGTGAACTGAATCCCCGCCATGCCCAATGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATACATCGCTGTTTACCCCACTCAACGCTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2K1SXY6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0K2E7Z9 |