254122

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1909973..1910492 Replicon chromosome
Accession NZ_CP102748
Organism Streptococcus suis strain Transconjugant cSFJ45

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2K1SXY6
Locus tag NWE21_RS09440 Protein ID WP_012775363.1
Coordinates 1909973..1910230 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag NWE21_RS09445 Protein ID WP_002939010.1
Coordinates 1910232..1910492 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWE21_RS09425 (NWE21_09435) 1906442..1908172 - 1731 WP_012775361.1 membrane protein -
NWE21_RS09430 (NWE21_09440) 1908537..1909409 - 873 WP_012775362.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
NWE21_RS09435 (NWE21_09445) 1909429..1909959 - 531 WP_009910909.1 DUF1697 domain-containing protein -
NWE21_RS09440 (NWE21_09450) 1909973..1910230 - 258 WP_012775363.1 Txe/YoeB family addiction module toxin Toxin
NWE21_RS09445 (NWE21_09455) 1910232..1910492 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NWE21_RS09450 (NWE21_09460) 1910568..1911023 - 456 WP_012028534.1 8-oxo-dGTP diphosphatase -
NWE21_RS09455 (NWE21_09465) 1911030..1911359 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin -
NWE21_RS09460 (NWE21_09470) 1911349..1911636 - 288 WP_012028535.1 hypothetical protein -
NWE21_RS09465 (NWE21_09475) 1911734..1912102 - 369 WP_012775453.1 hypothetical protein -
NWE21_RS09470 (NWE21_09480) 1912095..1912664 - 570 WP_012775366.1 ribonuclease M5 -
NWE21_RS09475 (NWE21_09485) 1912648..1913430 - 783 WP_012028536.1 TatD family hydrolase -
NWE21_RS09480 (NWE21_09490) 1913537..1913674 - 138 WP_002939016.1 50S ribosomal protein L34 -
NWE21_RS09485 (NWE21_09495) 1913842..1914837 - 996 WP_012775367.1 RNA-binding cell elongation regulator Jag/EloR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1870203..1913430 43227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10346.81 Da        Isoelectric Point: 7.2737

>T254122 WP_012775363.1 NZ_CP102748:c1910230-1909973 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIQDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR

Download         Length: 258 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT254122 WP_002939010.1 NZ_CP102748:c1910492-1910232 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1SXY6

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References