214275

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1879539..1880058 Replicon chromosome
Accession NZ_CP082197
Organism Streptococcus suis strain Transconjugant cSS389

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2K1SXY6
Locus tag K6975_RS09150 Protein ID WP_012775363.1
Coordinates 1879539..1879796 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag K6975_RS09155 Protein ID WP_002939010.1
Coordinates 1879798..1880058 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6975_RS09135 (K6975_09135) 1876008..1877738 - 1731 WP_012775361.1 membrane protein -
K6975_RS09140 (K6975_09140) 1878103..1878975 - 873 WP_012775362.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
K6975_RS09145 (K6975_09145) 1878995..1879525 - 531 WP_009910909.1 DUF1697 domain-containing protein -
K6975_RS09150 (K6975_09150) 1879539..1879796 - 258 WP_012775363.1 Txe/YoeB family addiction module toxin Toxin
K6975_RS09155 (K6975_09155) 1879798..1880058 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K6975_RS09160 (K6975_09160) 1880134..1880589 - 456 WP_012028534.1 8-oxo-dGTP diphosphatase -
K6975_RS09165 (K6975_09165) 1880596..1880925 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin -
K6975_RS09170 (K6975_09170) 1880915..1881202 - 288 WP_012028535.1 hypothetical protein -
K6975_RS09175 (K6975_09175) 1881300..1881668 - 369 WP_012775453.1 hypothetical protein -
K6975_RS09180 (K6975_09180) 1881661..1882230 - 570 WP_012775366.1 ribonuclease M5 -
K6975_RS09185 (K6975_09185) 1882214..1882996 - 783 WP_012028536.1 TatD family hydrolase -
K6975_RS09190 (K6975_09190) 1883103..1883240 - 138 WP_002939016.1 50S ribosomal protein L34 -
K6975_RS09195 (K6975_09195) 1883408..1884403 - 996 WP_012775367.1 RNA-binding cell elongation regulator Jag/EloR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1839769..1882996 43227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10346.81 Da        Isoelectric Point: 7.2737

>T214275 WP_012775363.1 NZ_CP082197:c1879796-1879539 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIQDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR

Download         Length: 258 bp

>T214275 NZ_CP110018:c1309274-1309167 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT214275 WP_002939010.1 NZ_CP082197:c1880058-1879798 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp

>AT214275 NZ_CP110018:1309321-1309387 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1SXY6

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References