262469

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1893590..1894109 Replicon chromosome
Accession NZ_CP109941
Organism Streptococcus suis strain ID38828

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2K1SXY6
Locus tag OHM51_RS09310 Protein ID WP_012775363.1
Coordinates 1893590..1893847 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag OHM51_RS09315 Protein ID WP_002939010.1
Coordinates 1893849..1894109 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OHM51_RS09295 (OHM51_09295) 1890059..1891789 - 1731 WP_012775361.1 membrane protein -
OHM51_RS09300 (OHM51_09300) 1892154..1893026 - 873 WP_012775362.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
OHM51_RS09305 (OHM51_09305) 1893046..1893576 - 531 WP_009910909.1 DUF1697 domain-containing protein -
OHM51_RS09310 (OHM51_09310) 1893590..1893847 - 258 WP_012775363.1 Txe/YoeB family addiction module toxin Toxin
OHM51_RS09315 (OHM51_09315) 1893849..1894109 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OHM51_RS09320 (OHM51_09320) 1894185..1894640 - 456 WP_012028534.1 8-oxo-dGTP diphosphatase -
OHM51_RS09325 (OHM51_09325) 1894647..1894976 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin -
OHM51_RS09330 (OHM51_09330) 1894966..1895253 - 288 WP_012028535.1 hypothetical protein -
OHM51_RS09335 (OHM51_09335) 1895351..1895719 - 369 WP_012775453.1 hypothetical protein -
OHM51_RS09340 (OHM51_09340) 1895712..1896281 - 570 WP_012775366.1 ribonuclease M5 -
OHM51_RS09345 (OHM51_09345) 1896265..1897047 - 783 WP_012028536.1 TatD family hydrolase -
OHM51_RS09350 (OHM51_09350) 1897154..1897291 - 138 WP_002939016.1 50S ribosomal protein L34 -
OHM51_RS09355 (OHM51_09355) 1897459..1898454 - 996 WP_012775367.1 RNA-binding cell elongation regulator Jag/EloR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1853820..1897047 43227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10346.81 Da        Isoelectric Point: 7.2737

>T262469 WP_012775363.1 NZ_CP109941:c1893847-1893590 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIQDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR

Download         Length: 258 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT262469 WP_002939010.1 NZ_CP109941:c1894109-1893849 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1SXY6

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References