233291

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1887993..1888512 Replicon chromosome
Accession NZ_CP091422
Organism Streptococcus suis strain LSM157

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2K1SXY6
Locus tag L3X06_RS09260 Protein ID WP_012775363.1
Coordinates 1887993..1888250 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag L3X06_RS09265 Protein ID WP_002939010.1
Coordinates 1888252..1888512 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3X06_RS09245 (L3X06_09245) 1884462..1886192 - 1731 WP_012775361.1 membrane protein -
L3X06_RS09250 (L3X06_09250) 1886557..1887429 - 873 WP_012775362.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
L3X06_RS09255 (L3X06_09255) 1887449..1887979 - 531 WP_009910909.1 DUF1697 domain-containing protein -
L3X06_RS09260 (L3X06_09260) 1887993..1888250 - 258 WP_012775363.1 Txe/YoeB family addiction module toxin Toxin
L3X06_RS09265 (L3X06_09265) 1888252..1888512 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
L3X06_RS09270 (L3X06_09270) 1888588..1889043 - 456 WP_012028534.1 8-oxo-dGTP diphosphatase -
L3X06_RS09275 (L3X06_09275) 1889050..1889379 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin -
L3X06_RS09280 (L3X06_09280) 1889369..1889656 - 288 WP_012028535.1 hypothetical protein -
L3X06_RS09285 (L3X06_09285) 1889754..1890122 - 369 WP_012775453.1 hypothetical protein -
L3X06_RS09290 (L3X06_09290) 1890115..1890684 - 570 WP_012775366.1 ribonuclease M5 -
L3X06_RS09295 (L3X06_09295) 1890668..1891450 - 783 WP_012028536.1 TatD family hydrolase -
L3X06_RS09300 (L3X06_09300) 1891557..1891694 - 138 WP_002939016.1 50S ribosomal protein L34 -
L3X06_RS09305 (L3X06_09305) 1891862..1892857 - 996 WP_012775367.1 RNA-binding cell elongation regulator Jag/EloR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1848223..1891450 43227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10346.81 Da        Isoelectric Point: 7.2737

>T233291 WP_012775363.1 NZ_CP091422:c1888250-1887993 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIQDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR

Download         Length: 258 bp

>T233291 NZ_HG326223:c3486045-3485623 [Serratia marcescens subsp. marcescens Db11]
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACCCAGCTTTTTTCCCTGTTGACTCATGGCGTTCTGATCTT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGTTATGGCCCGCTTTGGCTGGTGCTGCTGACGCTGGTGGTGTTTCAGTGCA
TTCGTAGCCAGAAGCGCATCGCCGCAGTGCAGGGCGAGCTGCGGCTGCTGGCGGACCGGCGTTTCAGCTGGCACGGCCGA
GAATGGCGGCTGGCGAAAAAGCCCTGGATGCCGGGCTACGGCCTGCTGCTGACGCTGCAGCCGATGGAAGGCAAAAAGCG
CCGCCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAGTGGCGCCACCTGCGGCAGCTGTTGCTGTATCCGCCGG
CGGGTAACGGCGAGGAACCCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT233291 WP_002939010.1 NZ_CP091422:c1888512-1888252 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp

>AT233291 NZ_HG326223:c3486292-3486026 [Serratia marcescens subsp. marcescens Db11]
ATGGATATTAACAACAAAGCACGTATTCACTGGGCTTGCCGTCGTGGCATGCGCGAGCTGGACATCTCCATCATGCCGTT
CTTCGAATACGAATACGACAGCCTGAATGACGCGGACAAGGCGCTGTTTATCCGCCTGCTGGAGTGTGACGATCCCGATC
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGACGGCGAGCTGCAGAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1SXY6

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References