242044

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 197509..198115 Replicon chromosome
Accession NZ_CP095463
Organism Streptococcus suis strain TJS56

Toxin (Protein)


Gene name parE Uniprot ID A0A0Z8ZB64
Locus tag MU520_RS00920 Protein ID WP_012775364.1
Coordinates 197786..198115 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID D5AKB4
Locus tag MU520_RS00915 Protein ID WP_012028535.1
Coordinates 197509..197796 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU520_RS00880 193133..193492 + 360 WP_004194560.1 ribonuclease P protein component -
MU520_RS00885 193476..194288 + 813 WP_012027897.1 YidC/Oxa1 family membrane protein insertase -
MU520_RS00890 194308..195303 + 996 WP_012775367.1 RNA-binding cell elongation regulator Jag/EloR -
MU520_RS00895 195471..195608 + 138 WP_002939016.1 50S ribosomal protein L34 -
MU520_RS00900 195715..196497 + 783 WP_012028536.1 TatD family hydrolase -
MU520_RS00905 196481..197050 + 570 WP_012775366.1 ribonuclease M5 -
MU520_RS00910 197043..197411 + 369 WP_012775453.1 hypothetical protein -
MU520_RS00915 197509..197796 + 288 WP_012028535.1 hypothetical protein Antitoxin
MU520_RS00920 197786..198115 + 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MU520_RS00925 198122..198577 + 456 WP_012028534.1 8-oxo-dGTP diphosphatase -
MU520_RS00930 198653..198913 + 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MU520_RS00935 198915..199172 + 258 WP_012775363.1 Txe/YoeB family addiction module toxin -
MU520_RS00940 199186..199716 + 531 WP_009910909.1 DUF1697 domain-containing protein -
MU520_RS00945 199736..200608 + 873 WP_012775362.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
MU520_RS00950 200973..202703 + 1731 WP_012775361.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 196481..239801 43320


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-95)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12562.52 Da        Isoelectric Point: 7.1991

>T242044 WP_012775364.1 NZ_CP095463:197786-198115 [Streptococcus suis]
MEFESYSVILAPAVEKELAVIYAYFSEQFSEEIAKRRIGMIVEALESLQIFPERGFNADNRFGKQIDPPHLTRGYVVGKD
YIALYRVVKNEVRVGHLFATKSDYVKLLK

Download         Length: 330 bp

>T242044 NZ_OV040719:c765269-764865 [Haemophilus influenzae]
ATGATTTATATGTTAGACACCAATATCATTATTTATTTAATGAAAAATCGCCCCAAAATTGTTGCCGAACGAGTATCACA
ATTATTGCCTAATGATCGCTTAGTTATCAGCTTTCTTACTTATGCTGAACTTATTAAAGGCGCCTTTGGTAGTCAAAATT
ATGAGCAATCAATACGAGCAATAGAATTACTTACTGAACGAGTAAATGTACTATATCCCAATGAACAAATCTGTTTACAT
TATGGCAAATGGGCAAATACACTCAAAAAACAAGGGAGACCTATCGGAAATAATGATCTATGGATTGCTTGTCACGCATT
GAGTTTAAATGCTGTTCTTATTACACATAATGTAAAAGAATTTCAGCGTATTACAGATCTTCAGTGGCAAGATTGGACAA
AATAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10892.43 Da        Isoelectric Point: 4.3464

>AT242044 WP_012028535.1 NZ_CP095463:197509-197796 [Streptococcus suis]
MITINKDAQVNFKTDSRLLEKAKEVFAMNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GHGISLESVKEKYGI

Download         Length: 288 bp

>AT242044 NZ_OV040719:c765502-765266 [Haemophilus influenzae]
ATGCTTGCTAAAGTGTTTCAAAGTGGTAACAGCCAAGCTGTTCGGATCCCGATGGACTTTCGTTTTGACGTCGATACCGT
AGAAATTTTCCGAAAGGAAAATGGGGATGTGGTATTACGCCCAGTTTCTAAAAAAACAGATGATTTTCTTGCGTTATTTG
AAGGATTTGATGAGACCTTTATTCAAGCACTTGAAGCGCGTGATGATTTACCGCCTCAGGAGCGAGAAAATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8ZB64

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9A6F4

References