253266

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1826946..1827552 Replicon chromosome
Accession NZ_CP102154
Organism Streptococcus suis strain SS15055_N2_C15

Toxin (Protein)


Gene name parE Uniprot ID A0A0Z8ZB64
Locus tag NQZ87_RS08935 Protein ID WP_012775364.1
Coordinates 1826946..1827275 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID D5AKB4
Locus tag NQZ87_RS08940 Protein ID WP_012028535.1
Coordinates 1827265..1827552 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ87_RS08905 (NQZ87_08905) 1822358..1824088 - 1731 WP_012775361.1 membrane protein -
NQZ87_RS08910 (NQZ87_08910) 1824453..1825325 - 873 WP_012775362.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
NQZ87_RS08915 (NQZ87_08915) 1825345..1825875 - 531 WP_009910909.1 DUF1697 domain-containing protein -
NQZ87_RS08920 (NQZ87_08920) 1825889..1826146 - 258 WP_012775363.1 Txe/YoeB family addiction module toxin -
NQZ87_RS08925 (NQZ87_08925) 1826148..1826408 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
NQZ87_RS08930 (NQZ87_08930) 1826484..1826939 - 456 WP_012028534.1 8-oxo-dGTP diphosphatase -
NQZ87_RS08935 (NQZ87_08935) 1826946..1827275 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NQZ87_RS08940 (NQZ87_08940) 1827265..1827552 - 288 WP_012028535.1 hypothetical protein Antitoxin
NQZ87_RS08945 (NQZ87_08945) 1827650..1828018 - 369 WP_012775453.1 hypothetical protein -
NQZ87_RS08950 (NQZ87_08950) 1828011..1828580 - 570 WP_012775366.1 ribonuclease M5 -
NQZ87_RS08955 (NQZ87_08955) 1828564..1829346 - 783 WP_012028536.1 TatD family hydrolase -
NQZ87_RS08960 (NQZ87_08960) 1829453..1829590 - 138 WP_002939016.1 50S ribosomal protein L34 -
NQZ87_RS08965 (NQZ87_08965) 1829758..1830753 - 996 WP_012775367.1 RNA-binding cell elongation regulator Jag/EloR -
NQZ87_RS08970 (NQZ87_08970) 1830773..1831585 - 813 WP_012027897.1 YidC/Oxa1 family membrane protein insertase -
NQZ87_RS08975 (NQZ87_08975) 1831569..1831928 - 360 WP_004194560.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1786118..1829346 43228


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-95)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12562.52 Da        Isoelectric Point: 7.1991

>T253266 WP_012775364.1 NZ_CP102154:c1827275-1826946 [Streptococcus suis]
MEFESYSVILAPAVEKELAVIYAYFSEQFSEEIAKRRIGMIVEALESLQIFPERGFNADNRFGKQIDPPHLTRGYVVGKD
YIALYRVVKNEVRVGHLFATKSDYVKLLK

Download         Length: 330 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10892.43 Da        Isoelectric Point: 4.3464

>AT253266 WP_012028535.1 NZ_CP102154:c1827552-1827265 [Streptococcus suis]
MITINKDAQVNFKTDSRLLEKAKEVFAMNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GHGISLESVKEKYGI

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8ZB64

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9A6F4

References