Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1893907..1894513 Replicon chromosome
Accession NZ_CP030017
Organism Streptococcus suis strain ISU1606

Toxin (Protein)


Gene name parE Uniprot ID A0A0Z8ZB64
Locus tag DK235_RS09270 Protein ID WP_012775364.1
Coordinates 1893907..1894236 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID D5AKB4
Locus tag DK235_RS09275 Protein ID WP_012028535.1
Coordinates 1894226..1894513 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DK235_RS09240 1889319..1891049 - 1731 WP_012775361.1 membrane protein -
DK235_RS09245 1891414..1892322 - 909 WP_012027884.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
DK235_RS09250 1892306..1892836 - 531 WP_009910909.1 DUF1697 domain-containing protein -
DK235_RS09255 1892850..1893107 - 258 WP_012775363.1 Txe/YoeB family addiction module toxin -
DK235_RS09260 1893109..1893369 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
DK235_RS09265 1893445..1893900 - 456 WP_012028534.1 8-oxo-dGTP diphosphatase -
DK235_RS09270 1893907..1894236 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DK235_RS09275 1894226..1894513 - 288 WP_012028535.1 hypothetical protein Antitoxin
DK235_RS09280 1894611..1894979 - 369 WP_012775453.1 hypothetical protein -
DK235_RS09285 1894972..1895541 - 570 WP_012775366.1 ribonuclease M5 -
DK235_RS09290 1895525..1896307 - 783 WP_012028536.1 TatD family hydrolase -
DK235_RS09295 1896414..1896551 - 138 WP_002939016.1 50S ribosomal protein L34 -
DK235_RS09300 1896719..1897714 - 996 WP_012775367.1 protein jag -
DK235_RS09305 1897734..1898546 - 813 WP_012027897.1 YidC/Oxa1 family membrane protein insertase -
DK235_RS09310 1898530..1898889 - 360 WP_004194560.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1853080..1896307 43227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-95)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12562.52 Da        Isoelectric Point: 7.1991

>T106863 WP_012775364.1 NZ_CP030017:c1894236-1893907 [Streptococcus suis]
MEFESYSVILAPAVEKELAVIYAYFSEQFSEEIAKRRIGMIVEALESLQIFPERGFNADNRFGKQIDPPHLTRGYVVGKD
YIALYRVVKNEVRVGHLFATKSDYVKLLK

Download         Length: 330 bp

>T106863 NZ_CP030017:c1894236-1893907 [Streptococcus suis]
ATGGAATTTGAGTCTTATTCAGTGATACTTGCTCCAGCAGTGGAGAAGGAATTGGCAGTTATTTACGCCTATTTTTCGGA
ACAGTTCTCAGAAGAAATTGCCAAAAGACGAATTGGGATGATTGTCGAAGCATTAGAGAGTTTGCAAATTTTTCCTGAAC
GTGGTTTTAACGCCGATAACCGTTTTGGTAAGCAGATAGACCCGCCTCATCTAACCCGAGGCTATGTCGTTGGAAAAGAC
TACATCGCCCTCTATCGCGTAGTGAAAAATGAAGTTCGAGTTGGTCATCTTTTTGCGACCAAGAGTGATTATGTGAAGTT
GTTGAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10892.43 Da        Isoelectric Point: 4.3464

>AT106863 WP_012028535.1 NZ_CP030017:c1894513-1894226 [Streptococcus suis]
MITINKDAQVNFKTDSRLLEKAKEVFAMNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GHGISLESVKEKYGI

Download         Length: 288 bp

>AT106863 NZ_CP030017:c1894513-1894226 [Streptococcus suis]
TTGATAACTATAAATAAAGATGCCCAAGTAAATTTTAAAACTGATTCCAGACTTTTAGAAAAAGCCAAGGAAGTATTTGC
TATGAACCAGCTGGATTTGACTGCTGGTTTTAACCTCTTCTTGCAAAATATCGCTGTAAAAAATGAGTTGCCAATTCTGA
CAGAAGAAGAGTTGGAAAGAGAAGAGTTGTTTTTACAGTTACAGAAGGAAATCCAGGAAAACCAACAGGCGATTGAGGCA
GGTCACGGGATCAGCCTAGAAAGTGTCAAAGAGAAGTATGGAATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8ZB64

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9A6F4

References