24010

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1966071..1966677 Replicon chromosome
Accession NC_012926
Organism Streptococcus suis BM407

Toxin (Protein)


Gene name parE Uniprot ID A0A0Z8ZB64
Locus tag SSUBM407_RS09620 Protein ID WP_012775364.1
Coordinates 1966071..1966400 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID D5AKB4
Locus tag SSUBM407_RS09625 Protein ID WP_012028535.1
Coordinates 1966390..1966677 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSUBM407_RS09590 1961483..1963213 - 1731 WP_012775361.1 membrane protein -
SSUBM407_RS09595 1963578..1964486 - 909 WP_012027884.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
SSUBM407_RS09600 1964470..1965000 - 531 WP_009910909.1 DUF1697 domain-containing protein -
SSUBM407_RS09605 1965014..1965271 - 258 WP_012775363.1 Txe/YoeB family addiction module toxin -
SSUBM407_RS09610 1965273..1965533 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
SSUBM407_RS09615 1965609..1966064 - 456 WP_012028534.1 8-oxo-dGTP diphosphatase -
SSUBM407_RS09620 1966071..1966400 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SSUBM407_RS09625 1966390..1966677 - 288 WP_012028535.1 hypothetical protein Antitoxin
SSUBM407_RS09630 1966775..1967143 - 369 WP_012775453.1 hypothetical protein -
SSUBM407_RS09635 1967136..1967705 - 570 WP_012775700.1 ribonuclease M5 -
SSUBM407_RS09640 1967689..1968471 - 783 WP_012028536.1 TatD family hydrolase -
SSUBM407_RS09645 1968578..1968715 - 138 WP_002939016.1 50S ribosomal protein L34 -
SSUBM407_RS09650 1968883..1969878 - 996 WP_012775367.1 protein jag -
SSUBM407_RS09655 1969898..1970710 - 813 WP_012027897.1 YidC/Oxa1 family membrane protein insertase -
SSUBM407_RS09660 1970694..1971053 - 360 WP_004194560.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1925244..1968471 43227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-95)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12562.52 Da        Isoelectric Point: 7.1991

>T24010 WP_012775364.1 NC_012926:c1966400-1966071 [Streptococcus suis BM407]
MEFESYSVILAPAVEKELAVIYAYFSEQFSEEIAKRRIGMIVEALESLQIFPERGFNADNRFGKQIDPPHLTRGYVVGKD
YIALYRVVKNEVRVGHLFATKSDYVKLLK

Download         Length: 330 bp

>T24010 NC_012926:c1966400-1966071 [Streptococcus suis BM407]
ATGGAATTTGAGTCTTATTCAGTGATACTTGCTCCAGCAGTGGAGAAGGAATTGGCAGTTATTTACGCCTATTTTTCGGA
ACAGTTCTCAGAAGAAATTGCCAAAAGACGAATTGGGATGATTGTCGAAGCATTGGAGAGTTTGCAAATTTTTCCTGAAC
GTGGTTTTAACGCCGATAACCGTTTTGGTAAGCAGATAGACCCGCCTCATCTAACCCGAGGCTATGTCGTTGGAAAAGAC
TACATCGCCCTCTATCGCGTAGTGAAAAATGAAGTTCGAGTTGGTCATCTTTTTGCGACCAAGAGTGATTATGTGAAGTT
GTTGAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10892.43 Da        Isoelectric Point: 4.3464

>AT24010 WP_012028535.1 NC_012926:c1966677-1966390 [Streptococcus suis BM407]
MITINKDAQVNFKTDSRLLEKAKEVFAMNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GHGISLESVKEKYGI

Download         Length: 288 bp

>AT24010 NC_012926:c1966677-1966390 [Streptococcus suis BM407]
TTGATAACTATAAATAAAGATGCCCAAGTAAATTTTAAAACTGATTCCAGACTTTTAGAAAAAGCCAAGGAAGTATTTGC
TATGAACCAGCTGGATTTGACTGCTGGTTTTAACCTCTTCTTGCAAAATATCGCTGTAAAAAATGAGTTGCCAATTCTGA
CAGAAGAAGAGTTGGAAAGAGAAGAGTTGTTTTTACAGTTACAGAAGGAAATCCAGGAAAACCAACAGGCGATTGAGGCA
GGTCACGGGATCAGCCTAGAAAGTGTCAAAGAGAAGTATGGAATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8ZB64

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9A6F4

References