Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1915890..1916496 Replicon chromosome
Accession NZ_CP020863
Organism Streptococcus suis strain SC19

Toxin (Protein)


Gene name parE Uniprot ID A0A0Z8ZB64
Locus tag B9H01_RS09660 Protein ID WP_012775364.1
Coordinates 1915890..1916219 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID D5AKB4
Locus tag B9H01_RS09665 Protein ID WP_012028535.1
Coordinates 1916209..1916496 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B9H01_RS09630 1911302..1913032 - 1731 WP_012775361.1 membrane protein -
B9H01_RS09635 1913397..1914305 - 909 WP_012027884.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
B9H01_RS09640 1914289..1914819 - 531 WP_009910909.1 DUF1697 domain-containing protein -
B9H01_RS09645 1914833..1915090 - 258 WP_012775363.1 Txe/YoeB family addiction module toxin -
B9H01_RS09650 1915092..1915352 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
B9H01_RS09655 1915428..1915883 - 456 WP_012028534.1 8-oxo-dGTP diphosphatase -
B9H01_RS09660 1915890..1916219 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B9H01_RS09665 1916209..1916496 - 288 WP_012028535.1 hypothetical protein Antitoxin
B9H01_RS09670 1916594..1916962 - 369 WP_012775365.1 hypothetical protein -
B9H01_RS09675 1916955..1917524 - 570 WP_012775366.1 ribonuclease M5 -
B9H01_RS09680 1917508..1918290 - 783 WP_012028536.1 TatD family hydrolase -
B9H01_RS09685 1918397..1918534 - 138 WP_002939016.1 50S ribosomal protein L34 -
B9H01_RS09690 1918702..1919697 - 996 WP_012775367.1 protein jag -
B9H01_RS09695 1919717..1920529 - 813 WP_012027897.1 YidC/Oxa1 family membrane protein insertase -
B9H01_RS09700 1920513..1920872 - 360 WP_004194560.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1875063..1918290 43227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-95)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12562.52 Da        Isoelectric Point: 7.1991

>T75587 WP_012775364.1 NZ_CP020863:c1916219-1915890 [Streptococcus suis]
MEFESYSVILAPAVEKELAVIYAYFSEQFSEEIAKRRIGMIVEALESLQIFPERGFNADNRFGKQIDPPHLTRGYVVGKD
YIALYRVVKNEVRVGHLFATKSDYVKLLK

Download         Length: 330 bp

>T75587 NZ_CP020863:c1916219-1915890 [Streptococcus suis]
ATGGAATTTGAGTCTTATTCAGTGATACTTGCTCCAGCAGTGGAGAAGGAATTGGCAGTTATTTACGCCTATTTTTCGGA
ACAGTTCTCAGAAGAAATTGCCAAAAGACGAATTGGGATGATTGTCGAAGCATTAGAGAGTTTGCAAATTTTTCCTGAAC
GTGGTTTTAACGCCGATAACCGTTTTGGTAAGCAGATAGACCCGCCTCATCTAACCCGAGGCTATGTCGTTGGAAAAGAC
TACATCGCCCTCTATCGCGTAGTGAAAAATGAAGTTCGAGTTGGTCATCTTTTTGCGACCAAGAGTGATTATGTGAAGTT
GTTGAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10892.43 Da        Isoelectric Point: 4.3464

>AT75587 WP_012028535.1 NZ_CP020863:c1916496-1916209 [Streptococcus suis]
MITINKDAQVNFKTDSRLLEKAKEVFAMNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GHGISLESVKEKYGI

Download         Length: 288 bp

>AT75587 NZ_CP020863:c1916496-1916209 [Streptococcus suis]
TTGATAACTATAAATAAAGATGCCCAAGTAAATTTTAAAACTGATTCCAGACTTTTAGAAAAAGCCAAGGAAGTATTTGC
TATGAACCAGCTGGATTTGACTGCTGGTTTTAACCTCTTCTTGCAAAATATCGCTGTAAAAAATGAGTTGCCAATTCTGA
CAGAAGAAGAGTTGGAAAGAGAAGAGTTGTTTTTACAGTTACAGAAGGAAATCCAGGAAAACCAACAGGCGATTGAGGCA
GGTCACGGGATCAGCCTAGAAAGTGTCAAAGAGAAGTATGGAATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8ZB64

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9A6F4

References