Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1957982..1958588 Replicon chromosome
Accession NC_020526
Organism Streptococcus suis SC070731

Toxin (Protein)


Gene name parE Uniprot ID A0A0Z8ZB64
Locus tag NJAUSS_RS09650 Protein ID WP_012775364.1
Coordinates 1957982..1958311 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID D5AKB4
Locus tag NJAUSS_RS09655 Protein ID WP_012028535.1
Coordinates 1958301..1958588 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NJAUSS_RS09620 1953394..1955124 - 1731 WP_012775361.1 membrane protein -
NJAUSS_RS09625 1955489..1956397 - 909 WP_012027884.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
NJAUSS_RS09630 1956381..1956911 - 531 WP_009910909.1 DUF1697 domain-containing protein -
NJAUSS_RS09635 1956925..1957182 - 258 WP_012775363.1 Txe/YoeB family addiction module toxin -
NJAUSS_RS09640 1957184..1957444 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
NJAUSS_RS09645 1957520..1957975 - 456 WP_012028534.1 8-oxo-dGTP diphosphatase -
NJAUSS_RS09650 1957982..1958311 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NJAUSS_RS09655 1958301..1958588 - 288 WP_012028535.1 hypothetical protein Antitoxin
NJAUSS_RS09660 1958686..1959054 - 369 WP_012775453.1 hypothetical protein -
NJAUSS_RS09665 1959047..1959616 - 570 WP_012775366.1 ribonuclease M5 -
NJAUSS_RS09670 1959600..1960382 - 783 WP_012028536.1 TatD family hydrolase -
NJAUSS_RS09675 1960489..1960626 - 138 WP_002939016.1 50S ribosomal protein L34 -
NJAUSS_RS09680 1960794..1961789 - 996 WP_012775367.1 protein jag -
NJAUSS_RS09685 1961809..1962621 - 813 WP_012027897.1 YidC/Oxa1 family membrane protein insertase -
NJAUSS_RS09690 1962605..1962964 - 360 WP_004194560.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1917155..1960382 43227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-95)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12562.52 Da        Isoelectric Point: 7.1991

>T29032 WP_012775364.1 NC_020526:c1958311-1957982 [Streptococcus suis SC070731]
MEFESYSVILAPAVEKELAVIYAYFSEQFSEEIAKRRIGMIVEALESLQIFPERGFNADNRFGKQIDPPHLTRGYVVGKD
YIALYRVVKNEVRVGHLFATKSDYVKLLK

Download         Length: 330 bp

>T29032 NC_020526:c1958311-1957982 [Streptococcus suis SC070731]
ATGGAATTTGAGTCTTATTCAGTGATACTTGCTCCAGCAGTGGAGAAGGAATTGGCAGTTATTTACGCCTATTTTTCGGA
ACAGTTCTCAGAAGAAATTGCCAAAAGACGAATTGGGATGATTGTCGAAGCATTAGAGAGTTTGCAAATTTTTCCTGAAC
GTGGTTTTAACGCCGATAACCGTTTTGGTAAGCAGATAGACCCGCCTCATCTAACCCGAGGCTATGTCGTTGGAAAAGAC
TACATCGCCCTCTATCGCGTAGTGAAAAATGAAGTTCGAGTTGGTCATCTTTTTGCGACCAAGAGTGATTATGTGAAGTT
GTTGAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10892.43 Da        Isoelectric Point: 4.3464

>AT29032 WP_012028535.1 NC_020526:c1958588-1958301 [Streptococcus suis SC070731]
MITINKDAQVNFKTDSRLLEKAKEVFAMNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GHGISLESVKEKYGI

Download         Length: 288 bp

>AT29032 NC_020526:c1958588-1958301 [Streptococcus suis SC070731]
TTGATAACTATAAATAAAGATGCCCAAGTAAATTTTAAAACTGATTCCAGACTTTTAGAAAAAGCCAAGGAAGTATTTGC
TATGAACCAGCTGGATTTGACTGCTGGTTTTAACCTCTTCTTGCAAAATATCGCTGTAAAAAATGAGTTGCCAATTCTGA
CAGAAGAAGAGTTGGAAAGAGAAGAGTTGTTTTTACAGTTACAGAAGGAAATCCAGGAAAACCAACAGGCGATTGAGGCA
GGTCACGGGATCAGCCTAGAAAGTGTCAAAGAGAAGTATGGAATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8ZB64

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9A6F4

References