Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parDE/RelB(antitoxin) |
Location | 1957982..1958588 | Replicon | chromosome |
Accession | NC_020526 | ||
Organism | Streptococcus suis SC070731 |
Toxin (Protein)
Gene name | parE | Uniprot ID | A0A0Z8ZB64 |
Locus tag | NJAUSS_RS09650 | Protein ID | WP_012775364.1 |
Coordinates | 1957982..1958311 (-) | Length | 110 a.a. |
Antitoxin (Protein)
Gene name | parD | Uniprot ID | D5AKB4 |
Locus tag | NJAUSS_RS09655 | Protein ID | WP_012028535.1 |
Coordinates | 1958301..1958588 (-) | Length | 96 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
NJAUSS_RS09620 | 1953394..1955124 | - | 1731 | WP_012775361.1 | membrane protein | - |
NJAUSS_RS09625 | 1955489..1956397 | - | 909 | WP_012027884.1 | 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA | - |
NJAUSS_RS09630 | 1956381..1956911 | - | 531 | WP_009910909.1 | DUF1697 domain-containing protein | - |
NJAUSS_RS09635 | 1956925..1957182 | - | 258 | WP_012775363.1 | Txe/YoeB family addiction module toxin | - |
NJAUSS_RS09640 | 1957184..1957444 | - | 261 | WP_002939010.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
NJAUSS_RS09645 | 1957520..1957975 | - | 456 | WP_012028534.1 | 8-oxo-dGTP diphosphatase | - |
NJAUSS_RS09650 | 1957982..1958311 | - | 330 | WP_012775364.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
NJAUSS_RS09655 | 1958301..1958588 | - | 288 | WP_012028535.1 | hypothetical protein | Antitoxin |
NJAUSS_RS09660 | 1958686..1959054 | - | 369 | WP_012775453.1 | hypothetical protein | - |
NJAUSS_RS09665 | 1959047..1959616 | - | 570 | WP_012775366.1 | ribonuclease M5 | - |
NJAUSS_RS09670 | 1959600..1960382 | - | 783 | WP_012028536.1 | TatD family hydrolase | - |
NJAUSS_RS09675 | 1960489..1960626 | - | 138 | WP_002939016.1 | 50S ribosomal protein L34 | - |
NJAUSS_RS09680 | 1960794..1961789 | - | 996 | WP_012775367.1 | protein jag | - |
NJAUSS_RS09685 | 1961809..1962621 | - | 813 | WP_012027897.1 | YidC/Oxa1 family membrane protein insertase | - |
NJAUSS_RS09690 | 1962605..1962964 | - | 360 | WP_004194560.1 | ribonuclease P protein component | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | - | 1917155..1960382 | 43227 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 110 a.a. Molecular weight: 12562.52 Da Isoelectric Point: 7.1991
>T29032 WP_012775364.1 NC_020526:c1958311-1957982 [Streptococcus suis SC070731]
MEFESYSVILAPAVEKELAVIYAYFSEQFSEEIAKRRIGMIVEALESLQIFPERGFNADNRFGKQIDPPHLTRGYVVGKD
YIALYRVVKNEVRVGHLFATKSDYVKLLK
MEFESYSVILAPAVEKELAVIYAYFSEQFSEEIAKRRIGMIVEALESLQIFPERGFNADNRFGKQIDPPHLTRGYVVGKD
YIALYRVVKNEVRVGHLFATKSDYVKLLK
Download Length: 330 bp
>T29032 NC_020526:c1958311-1957982 [Streptococcus suis SC070731]
ATGGAATTTGAGTCTTATTCAGTGATACTTGCTCCAGCAGTGGAGAAGGAATTGGCAGTTATTTACGCCTATTTTTCGGA
ACAGTTCTCAGAAGAAATTGCCAAAAGACGAATTGGGATGATTGTCGAAGCATTAGAGAGTTTGCAAATTTTTCCTGAAC
GTGGTTTTAACGCCGATAACCGTTTTGGTAAGCAGATAGACCCGCCTCATCTAACCCGAGGCTATGTCGTTGGAAAAGAC
TACATCGCCCTCTATCGCGTAGTGAAAAATGAAGTTCGAGTTGGTCATCTTTTTGCGACCAAGAGTGATTATGTGAAGTT
GTTGAAGTGA
ATGGAATTTGAGTCTTATTCAGTGATACTTGCTCCAGCAGTGGAGAAGGAATTGGCAGTTATTTACGCCTATTTTTCGGA
ACAGTTCTCAGAAGAAATTGCCAAAAGACGAATTGGGATGATTGTCGAAGCATTAGAGAGTTTGCAAATTTTTCCTGAAC
GTGGTTTTAACGCCGATAACCGTTTTGGTAAGCAGATAGACCCGCCTCATCTAACCCGAGGCTATGTCGTTGGAAAAGAC
TACATCGCCCTCTATCGCGTAGTGAAAAATGAAGTTCGAGTTGGTCATCTTTTTGCGACCAAGAGTGATTATGTGAAGTT
GTTGAAGTGA
Antitoxin
Download Length: 96 a.a. Molecular weight: 10892.43 Da Isoelectric Point: 4.3464
>AT29032 WP_012028535.1 NC_020526:c1958588-1958301 [Streptococcus suis SC070731]
MITINKDAQVNFKTDSRLLEKAKEVFAMNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GHGISLESVKEKYGI
MITINKDAQVNFKTDSRLLEKAKEVFAMNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GHGISLESVKEKYGI
Download Length: 288 bp
>AT29032 NC_020526:c1958588-1958301 [Streptococcus suis SC070731]
TTGATAACTATAAATAAAGATGCCCAAGTAAATTTTAAAACTGATTCCAGACTTTTAGAAAAAGCCAAGGAAGTATTTGC
TATGAACCAGCTGGATTTGACTGCTGGTTTTAACCTCTTCTTGCAAAATATCGCTGTAAAAAATGAGTTGCCAATTCTGA
CAGAAGAAGAGTTGGAAAGAGAAGAGTTGTTTTTACAGTTACAGAAGGAAATCCAGGAAAACCAACAGGCGATTGAGGCA
GGTCACGGGATCAGCCTAGAAAGTGTCAAAGAGAAGTATGGAATTTGA
TTGATAACTATAAATAAAGATGCCCAAGTAAATTTTAAAACTGATTCCAGACTTTTAGAAAAAGCCAAGGAAGTATTTGC
TATGAACCAGCTGGATTTGACTGCTGGTTTTAACCTCTTCTTGCAAAATATCGCTGTAAAAAATGAGTTGCCAATTCTGA
CAGAAGAAGAGTTGGAAAGAGAAGAGTTGTTTTTACAGTTACAGAAGGAAATCCAGGAAAACCAACAGGCGATTGAGGCA
GGTCACGGGATCAGCCTAGAAAGTGTCAAAGAGAAGTATGGAATTTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0Z8ZB64 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0Z9A6F4 |