106876

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1883797..1884403 Replicon chromosome
Accession NZ_CP030022
Organism Streptococcus suis strain ISU2714

Toxin (Protein)


Gene name parE Uniprot ID A0A0Z8ZB64
Locus tag DK876_RS09175 Protein ID WP_012775364.1
Coordinates 1883797..1884126 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID D5AKB4
Locus tag DK876_RS09180 Protein ID WP_012028535.1
Coordinates 1884116..1884403 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DK876_RS09145 1879209..1880939 - 1731 WP_012775361.1 membrane protein -
DK876_RS09150 1881304..1882212 - 909 WP_012027884.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
DK876_RS09155 1882196..1882726 - 531 WP_009910909.1 DUF1697 domain-containing protein -
DK876_RS09160 1882740..1882997 - 258 WP_012775363.1 Txe/YoeB family addiction module toxin -
DK876_RS09165 1882999..1883259 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
DK876_RS09170 1883335..1883790 - 456 WP_012028534.1 8-oxo-dGTP diphosphatase -
DK876_RS09175 1883797..1884126 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DK876_RS09180 1884116..1884403 - 288 WP_012028535.1 hypothetical protein Antitoxin
DK876_RS09185 1884501..1884869 - 369 WP_012775453.1 hypothetical protein -
DK876_RS09190 1884862..1885431 - 570 WP_012775366.1 ribonuclease M5 -
DK876_RS09195 1885415..1886197 - 783 WP_012028536.1 TatD family hydrolase -
DK876_RS09200 1886304..1886441 - 138 WP_002939016.1 50S ribosomal protein L34 -
DK876_RS09205 1886609..1887604 - 996 WP_012775367.1 protein jag -
DK876_RS09210 1887624..1888436 - 813 WP_012027897.1 YidC/Oxa1 family membrane protein insertase -
DK876_RS09215 1888420..1888779 - 360 WP_004194560.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1842970..1886197 43227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-95)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12562.52 Da        Isoelectric Point: 7.1991

>T106876 WP_012775364.1 NZ_CP030022:c1884126-1883797 [Streptococcus suis]
MEFESYSVILAPAVEKELAVIYAYFSEQFSEEIAKRRIGMIVEALESLQIFPERGFNADNRFGKQIDPPHLTRGYVVGKD
YIALYRVVKNEVRVGHLFATKSDYVKLLK

Download         Length: 330 bp

>T106876 NZ_CP030022:c1884126-1883797 [Streptococcus suis]
ATGGAATTTGAGTCTTATTCAGTGATACTTGCTCCAGCAGTGGAGAAGGAATTGGCAGTTATTTACGCCTATTTTTCGGA
ACAGTTCTCAGAAGAAATTGCCAAAAGACGAATTGGGATGATTGTCGAAGCATTAGAGAGTTTGCAAATTTTTCCTGAAC
GTGGTTTTAACGCCGATAACCGTTTTGGTAAGCAGATAGACCCGCCTCATCTAACCCGAGGCTATGTCGTTGGAAAAGAC
TACATCGCCCTCTATCGCGTAGTGAAAAATGAAGTTCGAGTTGGTCATCTTTTTGCGACCAAGAGTGATTATGTGAAGTT
GTTGAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10892.43 Da        Isoelectric Point: 4.3464

>AT106876 WP_012028535.1 NZ_CP030022:c1884403-1884116 [Streptococcus suis]
MITINKDAQVNFKTDSRLLEKAKEVFAMNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GHGISLESVKEKYGI

Download         Length: 288 bp

>AT106876 NZ_CP030022:c1884403-1884116 [Streptococcus suis]
TTGATAACTATAAATAAAGATGCCCAAGTAAATTTTAAAACTGATTCCAGACTTTTAGAAAAAGCCAAGGAAGTATTTGC
TATGAACCAGCTGGATTTGACTGCTGGTTTTAACCTCTTCTTGCAAAATATCGCTGTAAAAAATGAGTTGCCAATTCTGA
CAGAAGAAGAGTTGGAAAGAGAAGAGTTGTTTTTACAGTTACAGAAGGAAATCCAGGAAAACCAACAGGCGATTGAGGCA
GGTCACGGGATCAGCCTAGAAAGTGTCAAAGAGAAGTATGGAATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8ZB64

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9A6F4

References