27124

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1930175..1930781 Replicon chromosome
Accession NC_017619
Organism Streptococcus suis SS12

Toxin (Protein)


Gene name parE Uniprot ID A0A0Z8ZB64
Locus tag SSU12_RS09635 Protein ID WP_012775364.1
Coordinates 1930175..1930504 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID D5AKB4
Locus tag SSU12_RS09640 Protein ID WP_012028535.1
Coordinates 1930494..1930781 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSU12_RS09605 1925587..1927317 - 1731 WP_012775361.1 membrane protein -
SSU12_RS09610 1927682..1928590 - 909 WP_012027884.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
SSU12_RS09615 1928574..1929104 - 531 WP_009910909.1 DUF1697 domain-containing protein -
SSU12_RS09620 1929118..1929375 - 258 WP_012775363.1 Txe/YoeB family addiction module toxin -
SSU12_RS09625 1929377..1929637 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
SSU12_RS09630 1929713..1930168 - 456 WP_012028534.1 8-oxo-dGTP diphosphatase -
SSU12_RS09635 1930175..1930504 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SSU12_RS09640 1930494..1930781 - 288 WP_012028535.1 hypothetical protein Antitoxin
SSU12_RS09645 1930879..1931247 - 369 WP_012775453.1 hypothetical protein -
SSU12_RS09650 1931240..1931809 - 570 WP_012775366.1 ribonuclease M5 -
SSU12_RS09655 1931793..1932575 - 783 WP_012028536.1 TatD family hydrolase -
SSU12_RS09660 1932682..1932819 - 138 WP_002939016.1 50S ribosomal protein L34 -
SSU12_RS09665 1932987..1933982 - 996 WP_012775367.1 protein jag -
SSU12_RS09670 1934002..1934814 - 813 WP_012027897.1 YidC/Oxa1 family membrane protein insertase -
SSU12_RS09675 1934798..1935157 - 360 WP_004194560.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1888857..1932575 43718


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-95)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12562.52 Da        Isoelectric Point: 7.1991

>T27124 WP_012775364.1 NC_017619:c1930504-1930175 [Streptococcus suis SS12]
MEFESYSVILAPAVEKELAVIYAYFSEQFSEEIAKRRIGMIVEALESLQIFPERGFNADNRFGKQIDPPHLTRGYVVGKD
YIALYRVVKNEVRVGHLFATKSDYVKLLK

Download         Length: 330 bp

>T27124 NC_017619:c1930504-1930175 [Streptococcus suis SS12]
ATGGAATTTGAGTCTTATTCAGTGATACTTGCTCCAGCAGTGGAGAAGGAATTGGCAGTTATTTACGCCTATTTTTCGGA
ACAGTTCTCAGAAGAAATTGCCAAAAGACGAATTGGGATGATTGTCGAAGCATTAGAGAGTTTGCAAATTTTTCCTGAAC
GTGGTTTTAACGCCGATAACCGTTTTGGTAAGCAGATAGACCCGCCTCATCTAACCCGAGGCTATGTCGTTGGAAAAGAC
TACATCGCCCTCTATCGCGTAGTGAAAAATGAAGTTCGAGTTGGTCATCTTTTTGCGACCAAGAGTGATTATGTGAAGTT
GTTGAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10892.43 Da        Isoelectric Point: 4.3464

>AT27124 WP_012028535.1 NC_017619:c1930781-1930494 [Streptococcus suis SS12]
MITINKDAQVNFKTDSRLLEKAKEVFAMNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GHGISLESVKEKYGI

Download         Length: 288 bp

>AT27124 NC_017619:c1930781-1930494 [Streptococcus suis SS12]
TTGATAACTATAAATAAAGATGCCCAAGTAAATTTTAAAACTGATTCCAGACTTTTAGAAAAAGCCAAGGAAGTATTTGC
TATGAACCAGCTGGATTTGACTGCTGGTTTTAACCTCTTCTTGCAAAATATCGCTGTAAAAAATGAGTTGCCAATTCTGA
CAGAAGAAGAGTTGGAAAGAGAAGAGTTGTTTTTACAGTTACAGAAGGAAATCCAGGAAAACCAACAGGCGATTGAGGCA
GGTCACGGGATCAGCCTAGAAAGTGTCAAAGAGAAGTATGGAATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8ZB64

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9A6F4

References