28234

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1799671..1800190 Replicon chromosome
Accession NC_018526
Organism Streptococcus suis S735

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2K1SXY6
Locus tag YYK_RS08860 Protein ID WP_012775363.1
Coordinates 1799671..1799928 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag YYK_RS08865 Protein ID WP_002939010.1
Coordinates 1799930..1800190 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YYK_RS08845 1796140..1797870 - 1731 WP_012775361.1 membrane protein -
YYK_RS08850 1798235..1799143 - 909 WP_012027884.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
YYK_RS08855 1799127..1799657 - 531 WP_009910909.1 DUF1697 domain-containing protein -
YYK_RS08860 1799671..1799928 - 258 WP_012775363.1 Txe/YoeB family addiction module toxin Toxin
YYK_RS08865 1799930..1800190 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
YYK_RS08870 1800266..1800721 - 456 WP_012028534.1 8-oxo-dGTP diphosphatase -
YYK_RS08875 1800728..1801057 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin -
YYK_RS08880 1801047..1801334 - 288 WP_012028535.1 hypothetical protein -
YYK_RS08885 1801432..1801800 - 369 WP_014917322.1 hypothetical protein -
YYK_RS08890 1801793..1802362 - 570 WP_012775700.1 ribonuclease M5 -
YYK_RS08895 1802346..1803128 - 783 WP_012028536.1 TatD family hydrolase -
YYK_RS08900 1803235..1803372 - 138 WP_002939016.1 50S ribosomal protein L34 -
YYK_RS08905 1803540..1804535 - 996 WP_012775367.1 protein jag -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1759893..1803128 43235


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10346.81 Da        Isoelectric Point: 7.2737

>T28234 WP_012775363.1 NC_018526:c1799928-1799671 [Streptococcus suis S735]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIQDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR

Download         Length: 258 bp

>T28234 NC_018526:c1799928-1799671 [Streptococcus suis S735]
ATGGGAATCCATTTTACAGACGACGCCTGGGAAGACTATCTTTATTGGCAGGGTCAGGATAAGAAAACACTGAAGAGAAT
CAATAAGATTATCCAGGATATGCAGCGACATCCTTTTGAAGGCATTGCCAAACCAGAACCTTTGAAGTATGATTATCAAG
GTGCCTGGTCTCGGAGAATTGATGCGGAGAATCGGTTGATTTATATGGTGGAAGCTGATCGGTTGTGCATCCTGTCGCTA
AAGGATCATTATAGGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT28234 WP_002939010.1 NC_018526:c1800190-1799930 [Streptococcus suis S735]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp

>AT28234 NC_018526:c1800190-1799930 [Streptococcus suis S735]
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAGGACTATATGAAAAAGGTCAATGACGAGTTTGAACCTTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTACTCTCAAAGAGTGAGTGGGATAGTTTACAAGAAACCCTCG
CTGTTGCTCGGAACACTTATCTGTCTCAAAAAGTCCTACGTGGTATGGCTAAAGTCAAAACGGGACAAACCCAAGAACGA
AACCTGATAGAGGCGGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1SXY6

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References