Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1957568..1958174 Replicon chromosome
Accession NZ_CP024050
Organism Streptococcus suis strain CS100322

Toxin (Protein)


Gene name parE Uniprot ID A0A0Z8ZB64
Locus tag CR541_RS09955 Protein ID WP_012775364.1
Coordinates 1957568..1957897 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID D5AKB4
Locus tag CR541_RS09960 Protein ID WP_012028535.1
Coordinates 1957887..1958174 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CR541_RS09925 1952980..1954710 - 1731 WP_012775361.1 membrane protein -
CR541_RS09930 1955075..1955983 - 909 WP_012027884.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
CR541_RS09935 1955967..1956497 - 531 WP_009910909.1 DUF1697 domain-containing protein -
CR541_RS09940 1956511..1956768 - 258 WP_012775363.1 Txe/YoeB family addiction module toxin -
CR541_RS09945 1956770..1957030 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
CR541_RS09950 1957106..1957561 - 456 WP_012028534.1 8-oxo-dGTP diphosphatase -
CR541_RS09955 1957568..1957897 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CR541_RS09960 1957887..1958174 - 288 WP_012028535.1 hypothetical protein Antitoxin
CR541_RS09965 1958272..1958640 - 369 WP_012775453.1 hypothetical protein -
CR541_RS09970 1958633..1959202 - 570 WP_012775366.1 ribonuclease M5 -
CR541_RS09975 1959186..1959968 - 783 WP_012028536.1 TatD family hydrolase -
CR541_RS09980 1960075..1960212 - 138 WP_002939016.1 50S ribosomal protein L34 -
CR541_RS09985 1960380..1961375 - 996 WP_012775367.1 protein jag -
CR541_RS09990 1961395..1962207 - 813 WP_012027897.1 YidC/Oxa1 family membrane protein insertase -
CR541_RS09995 1962191..1962550 - 360 WP_004194560.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1916742..1959968 43226


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-95)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12562.52 Da        Isoelectric Point: 7.1991

>T86628 WP_012775364.1 NZ_CP024050:c1957897-1957568 [Streptococcus suis]
MEFESYSVILAPAVEKELAVIYAYFSEQFSEEIAKRRIGMIVEALESLQIFPERGFNADNRFGKQIDPPHLTRGYVVGKD
YIALYRVVKNEVRVGHLFATKSDYVKLLK

Download         Length: 330 bp

>T86628 NZ_CP024050:c1957897-1957568 [Streptococcus suis]
ATGGAATTTGAGTCTTATTCAGTGATACTTGCTCCAGCAGTGGAGAAGGAATTGGCAGTTATTTACGCCTATTTTTCGGA
ACAGTTCTCAGAAGAAATTGCCAAAAGACGAATTGGGATGATTGTCGAAGCATTAGAGAGTTTGCAAATTTTTCCTGAAC
GTGGTTTTAACGCCGATAACCGTTTTGGTAAGCAGATAGACCCGCCTCATCTAACCCGAGGCTATGTCGTTGGAAAAGAC
TACATCGCCCTCTATCGCGTAGTGAAAAATGAAGTTCGAGTTGGTCATCTTTTTGCGACCAAGAGTGATTATGTGAAGTT
GTTGAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10892.43 Da        Isoelectric Point: 4.3464

>AT86628 WP_012028535.1 NZ_CP024050:c1958174-1957887 [Streptococcus suis]
MITINKDAQVNFKTDSRLLEKAKEVFAMNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GHGISLESVKEKYGI

Download         Length: 288 bp

>AT86628 NZ_CP024050:c1958174-1957887 [Streptococcus suis]
TTGATAACTATAAATAAAGATGCCCAAGTAAATTTTAAAACTGATTCCAGACTTTTAGAAAAAGCCAAGGAAGTATTTGC
TATGAACCAGCTGGATTTGACTGCTGGTTTTAACCTCTTCTTGCAAAATATCGCTGTAAAAAATGAGTTGCCAATTCTGA
CAGAAGAAGAGTTGGAAAGAGAAGAGTTGTTTTTACAGTTACAGAAGGAAATCCAGGAAAACCAACAGGCGATTGAGGCA
GGTCACGGGATCAGCCTAGAAAGTGTCAAAGAGAAGTATGGAATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8ZB64

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9A6F4

References