Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1882740..1883259 Replicon chromosome
Accession NZ_CP030022
Organism Streptococcus suis strain ISU2714

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2K1SXY6
Locus tag DK876_RS09160 Protein ID WP_012775363.1
Coordinates 1882740..1882997 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag DK876_RS09165 Protein ID WP_002939010.1
Coordinates 1882999..1883259 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DK876_RS09145 1879209..1880939 - 1731 WP_012775361.1 membrane protein -
DK876_RS09150 1881304..1882212 - 909 WP_012027884.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
DK876_RS09155 1882196..1882726 - 531 WP_009910909.1 DUF1697 domain-containing protein -
DK876_RS09160 1882740..1882997 - 258 WP_012775363.1 Txe/YoeB family addiction module toxin Toxin
DK876_RS09165 1882999..1883259 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DK876_RS09170 1883335..1883790 - 456 WP_012028534.1 8-oxo-dGTP diphosphatase -
DK876_RS09175 1883797..1884126 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin -
DK876_RS09180 1884116..1884403 - 288 WP_012028535.1 hypothetical protein -
DK876_RS09185 1884501..1884869 - 369 WP_012775453.1 hypothetical protein -
DK876_RS09190 1884862..1885431 - 570 WP_012775366.1 ribonuclease M5 -
DK876_RS09195 1885415..1886197 - 783 WP_012028536.1 TatD family hydrolase -
DK876_RS09200 1886304..1886441 - 138 WP_002939016.1 50S ribosomal protein L34 -
DK876_RS09205 1886609..1887604 - 996 WP_012775367.1 protein jag -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1842970..1886197 43227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10346.81 Da        Isoelectric Point: 7.2737

>T106875 WP_012775363.1 NZ_CP030022:c1882997-1882740 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIQDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR

Download         Length: 258 bp

>T106875 NZ_CP030022:c1882997-1882740 [Streptococcus suis]
ATGGGAATCCATTTTACAGACGACGCCTGGGAAGACTATCTTTATTGGCAGGGTCAGGATAAGAAAACACTGAAGAGAAT
CAATAAGATTATCCAGGATATGCAGCGACATCCTTTTGAAGGCATTGCCAAACCAGAACCTTTGAAGTATGATTATCAAG
GTGCCTGGTCTCGGAGAATTGATGCGGAGAATCGGTTGATTTATATGGTGGAAGCTGATCGGTTGTGCATCCTGTCGCTA
AAGGATCATTATAGGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT106875 WP_002939010.1 NZ_CP030022:c1883259-1882999 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp

>AT106875 NZ_CP030022:c1883259-1882999 [Streptococcus suis]
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAGGACTATATGAAAAAGGTCAATGACGAGTTTGAACCTTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTACTCTCAAAGAGTGAGTGGGATAGTTTACAAGAAACCCTCG
CTGTTGCTCGGAACACTTATCTGTCTCAAAAAGTCCTACGTGGTATGGCTAAAGTCAAAACGGGACAAACCCAAGAACGA
AACCTGATAGAGGCGGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1SXY6

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References