288905

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1861752..1862271 Replicon chromosome
Accession NZ_LR738721
Organism Streptococcus suis isolate S10

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2K1SXY6
Locus tag GPW51_RS09335 Protein ID WP_012775363.1
Coordinates 1861752..1862009 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag GPW51_RS09340 Protein ID WP_002939010.1
Coordinates 1862011..1862271 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPW51_RS09320 1858221..1859951 - 1731 WP_012775361.1 membrane protein -
GPW51_RS09325 1860316..1861224 - 909 WP_012027884.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
GPW51_RS09330 1861208..1861738 - 531 WP_009910909.1 DUF1697 domain-containing protein -
GPW51_RS09335 1861752..1862009 - 258 WP_012775363.1 Txe/YoeB family addiction module toxin Toxin
GPW51_RS09340 1862011..1862271 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GPW51_RS09345 1862347..1862802 - 456 WP_012028534.1 8-oxo-dGTP diphosphatase -
GPW51_RS09350 1862809..1863138 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin -
GPW51_RS09355 1863128..1863415 - 288 WP_012028535.1 hypothetical protein -
GPW51_RS09360 1863513..1863881 - 369 WP_012775453.1 hypothetical protein -
GPW51_RS09365 1863874..1864443 - 570 WP_012775366.1 ribonuclease M5 -
GPW51_RS09370 1864427..1865209 - 783 WP_012028536.1 TatD family hydrolase -
GPW51_RS09375 1865316..1865453 - 138 WP_002939016.1 50S ribosomal protein L34 -
GPW51_RS09380 1865621..1866616 - 996 WP_012775367.1 protein jag -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1821982..1865209 43227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10346.81 Da        Isoelectric Point: 7.2737

>T288905 WP_012775363.1 NZ_LR738721:c1862009-1861752 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIQDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR

Download         Length: 258 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT288905 WP_002939010.1 NZ_LR738721:c1862271-1862011 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1SXY6

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References