220441

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1785365..1785971 Replicon chromosome
Accession NZ_CP085088
Organism Streptococcus suis strain Ssuis_MA1

Toxin (Protein)


Gene name parE Uniprot ID A0A0Z8ZB64
Locus tag LIO33_RS08770 Protein ID WP_012775364.1
Coordinates 1785365..1785694 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID D5AKB4
Locus tag LIO33_RS08775 Protein ID WP_012028535.1
Coordinates 1785684..1785971 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIO33_RS08740 1780777..1782507 - 1731 WP_012775361.1 membrane protein -
LIO33_RS08745 1782872..1783744 - 873 WP_012775362.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
LIO33_RS08750 1783764..1784294 - 531 WP_009910909.1 DUF1697 domain-containing protein -
LIO33_RS08755 1784308..1784565 - 258 WP_012775363.1 Txe/YoeB family addiction module toxin -
LIO33_RS08760 1784567..1784827 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
LIO33_RS08765 1784903..1785358 - 456 WP_012028534.1 8-oxo-dGTP diphosphatase -
LIO33_RS08770 1785365..1785694 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LIO33_RS08775 1785684..1785971 - 288 WP_012028535.1 hypothetical protein Antitoxin
LIO33_RS08780 1786069..1786437 - 369 WP_012775453.1 hypothetical protein -
LIO33_RS08785 1786430..1786999 - 570 WP_012775366.1 ribonuclease M5 -
LIO33_RS08790 1786983..1787765 - 783 WP_012028536.1 TatD family hydrolase -
LIO33_RS08795 1787872..1788009 - 138 WP_002939016.1 50S ribosomal protein L34 -
LIO33_RS08800 1788177..1789172 - 996 WP_012775367.1 RNA-binding cell elongation regulator Jag/EloR -
LIO33_RS08805 1789192..1790004 - 813 WP_012027897.1 YidC/Oxa1 family membrane protein insertase -
LIO33_RS08810 1789988..1790347 - 360 WP_004194560.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1744538..1787765 43227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-95)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12562.52 Da        Isoelectric Point: 7.1991

>T220441 WP_012775364.1 NZ_CP085088:c1785694-1785365 [Streptococcus suis]
MEFESYSVILAPAVEKELAVIYAYFSEQFSEEIAKRRIGMIVEALESLQIFPERGFNADNRFGKQIDPPHLTRGYVVGKD
YIALYRVVKNEVRVGHLFATKSDYVKLLK

Download         Length: 330 bp

>T220441 NZ_CP117024:120185-120466 [Helicobacter pylori]
ATGCTTAAAGTCAGAACTAAGAAAGATTTTCTTAAAGACTTTAATAAGCATATCTTATCCGGGCGTATTAAAGAAAGCGA
TGTTACAAGCATTGTTGATTGCCTAAAAAAACAAAAACCACTCCAACAAAAATATTGCGACCATGCTTTGAGTGGTAATC
TTAAAGGGCTGAGAGAGTGTCATGTCAAGCCAAACTTGTTATTGATTTATGAAATCAAAAAACAAGAAAACGAACTTGTT
TTATTGCGTCTAGACACTCATAGCGAGCTATTTAAAAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10892.43 Da        Isoelectric Point: 4.3464

>AT220441 WP_012028535.1 NZ_CP085088:c1785971-1785684 [Streptococcus suis]
MITINKDAQVNFKTDSRLLEKAKEVFAMNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GHGISLESVKEKYGI

Download         Length: 288 bp

>AT220441 NZ_CP117024:119878-120192 [Helicobacter pylori]
ATGTCAAATATTATTACAGATTACTCGCAATACAATGAAAAGCAACTGCACAATTTCCTAAACTCCATTGAAAAACAATT
GCTTAAGGCAGAAGGGGATAAAAATAAGGCGATAAAAAAAATCCAAGAGTGTGAATTGCAAGAACAAATGATCAGACAAG
TTTTAGCCCAAAAACATTCTCAAGAAAAAGAACCCACACCAAGTTTGTTAAATACGATCGCCTCAAAAGATGACCCAGAA
TACGATGTTTCGTTTGGAGACTTCAATGATTTTTTGCAAATAGCAAAACAAGAAAGAGAAAGGCATAATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8ZB64

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9A6F4

References