233296

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1975212..1975731 Replicon chromosome
Accession NZ_CP091423
Organism Streptococcus suis strain LSM29

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2K1SXY6
Locus tag L3X15_RS09675 Protein ID WP_012775363.1
Coordinates 1975212..1975469 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag L3X15_RS09680 Protein ID WP_002939010.1
Coordinates 1975471..1975731 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3X15_RS09660 (L3X15_09660) 1971681..1973411 - 1731 WP_012775361.1 membrane protein -
L3X15_RS09665 (L3X15_09665) 1973776..1974648 - 873 WP_012775362.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
L3X15_RS09670 (L3X15_09670) 1974668..1975198 - 531 WP_009910909.1 DUF1697 domain-containing protein -
L3X15_RS09675 (L3X15_09675) 1975212..1975469 - 258 WP_012775363.1 Txe/YoeB family addiction module toxin Toxin
L3X15_RS09680 (L3X15_09680) 1975471..1975731 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
L3X15_RS09685 (L3X15_09685) 1975807..1976262 - 456 WP_012028534.1 8-oxo-dGTP diphosphatase -
L3X15_RS09690 (L3X15_09690) 1976269..1976598 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin -
L3X15_RS09695 (L3X15_09695) 1976588..1976875 - 288 WP_012028535.1 hypothetical protein -
L3X15_RS09700 (L3X15_09700) 1976973..1977341 - 369 WP_012775453.1 hypothetical protein -
L3X15_RS09705 (L3X15_09705) 1977334..1977903 - 570 WP_012775366.1 ribonuclease M5 -
L3X15_RS09710 (L3X15_09710) 1977887..1978669 - 783 WP_012028536.1 TatD family hydrolase -
L3X15_RS09715 (L3X15_09715) 1978776..1978913 - 138 WP_002939016.1 50S ribosomal protein L34 -
L3X15_RS09720 (L3X15_09720) 1979081..1980076 - 996 WP_012775367.1 RNA-binding cell elongation regulator Jag/EloR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1935442..1978669 43227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10346.81 Da        Isoelectric Point: 7.2737

>T233296 WP_012775363.1 NZ_CP091423:c1975469-1975212 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIQDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR

Download         Length: 258 bp

>T233296 NZ_HG738867:c382291-382073 [Escherichia coli str. K-12 substr. MC4100]
ATGTCCGAAAAATTTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT233296 WP_002939010.1 NZ_CP091423:c1975731-1975471 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp

>AT233296 NZ_HG738867:c382691-382317 [Escherichia coli str. K-12 substr. MC4100]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1SXY6

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References