215681

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1957370..1957976 Replicon chromosome
Accession NZ_CP082948
Organism Streptococcus suis strain SZ1908

Toxin (Protein)


Gene name parE Uniprot ID A0A0Z8ZB64
Locus tag K8227_RS09585 Protein ID WP_012775364.1
Coordinates 1957370..1957699 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID D5AKB4
Locus tag K8227_RS09590 Protein ID WP_012028535.1
Coordinates 1957689..1957976 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8227_RS09555 (K8227_09530) 1952782..1954512 - 1731 WP_012775361.1 membrane protein -
K8227_RS09560 (K8227_09535) 1954877..1955749 - 873 WP_012775362.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
K8227_RS09565 (K8227_09540) 1955769..1956299 - 531 WP_009910909.1 DUF1697 domain-containing protein -
K8227_RS09570 (K8227_09545) 1956313..1956570 - 258 WP_211838284.1 Txe/YoeB family addiction module toxin -
K8227_RS09575 (K8227_09550) 1956572..1956832 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
K8227_RS09580 (K8227_09555) 1956908..1957363 - 456 WP_012028534.1 8-oxo-dGTP diphosphatase -
K8227_RS09585 (K8227_09560) 1957370..1957699 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K8227_RS09590 (K8227_09565) 1957689..1957976 - 288 WP_012028535.1 hypothetical protein Antitoxin
K8227_RS09595 (K8227_09570) 1958074..1958442 - 369 WP_012775453.1 hypothetical protein -
K8227_RS09600 (K8227_09575) 1958435..1959004 - 570 WP_012775366.1 ribonuclease M5 -
K8227_RS09605 (K8227_09580) 1958988..1959770 - 783 WP_012028536.1 TatD family hydrolase -
K8227_RS09610 (K8227_09585) 1959877..1960014 - 138 WP_002939016.1 50S ribosomal protein L34 -
K8227_RS09615 (K8227_09590) 1960182..1961177 - 996 WP_012775367.1 RNA-binding cell elongation regulator Jag/EloR -
K8227_RS09620 (K8227_09595) 1961197..1962009 - 813 WP_012027897.1 YidC/Oxa1 family membrane protein insertase -
K8227_RS09625 (K8227_09600) 1961993..1962352 - 360 WP_004194560.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1916543..1959770 43227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-95)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12562.52 Da        Isoelectric Point: 7.1991

>T215681 WP_012775364.1 NZ_CP082948:c1957699-1957370 [Streptococcus suis]
MEFESYSVILAPAVEKELAVIYAYFSEQFSEEIAKRRIGMIVEALESLQIFPERGFNADNRFGKQIDPPHLTRGYVVGKD
YIALYRVVKNEVRVGHLFATKSDYVKLLK

Download         Length: 330 bp

>T215681 NZ_CP110887:c4810379-4809975 [Dickeya solani]
ATGAACATACGGATTTTCAAGTCAACGCTGATCCGTCAACAATTGAGCCAGCAAGAGCTTGATGATTTGGTCGCGGATTT
TCACGCCTATAAGCAGAATGGGGTACTACCGGACACATTTGGGCGTGACGCGCCTTATGATGATGACCGAACCTATCCAT
TAGTAAAAGCAGAGCAGGTGGCTCACATCCACCTTGCCGATGCGGATGCGCCTTTTCCCAGGTTCTTGCGCCAGTTCAAG
AGAACCAGCGATCGGGCCCATTTGGTCTACTGCCAGGGAGCGATGGATCCCGAGGCCTGCCTGTTAATTATTATTTTAAA
ACCCGAAGCCCATAAAATGGCACGCAACAATAACAACATGCACAAGATCGGGATGATGGCCGCTGCGTTCAGGATGAAAT
ATTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10892.43 Da        Isoelectric Point: 4.3464

>AT215681 WP_012028535.1 NZ_CP082948:c1957976-1957689 [Streptococcus suis]
MITINKDAQVNFKTDSRLLEKAKEVFAMNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GHGISLESVKEKYGI

Download         Length: 288 bp

>AT215681 NZ_CP110887:c4810669-4810376 [Dickeya solani]
ATGGAGCGTATTCTTGCTGAAAAATCTATAAATATTACAGAGTTAAGGAAAAATCCGGCTAAGTATTTTATTGATGAGCC
TGTTGCCGTGCTTTCTAACAACCGGCCCGCCGGTTACATGGTGAGTGCCAAAGTCTTTGAAGAACTGATCGATCTGCTAG
AGGCGAAGCAGGAAACGGTTCATACCGTAGCGCGCTTTAGGCCAACGGCCGAACGTTTACGAGCCCTTGCAGATAGCGGT
CAGAAACTGCTGAATGATGCCTCTGGCAAGGATCTGACTGAGTTCACGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8ZB64

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9A6F4

References