Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1893233..1893752 Replicon chromosome
Accession NZ_CP102137
Organism Streptococcus suis strain M104300_S20

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2K1SXY6
Locus tag NQZ96_RS09245 Protein ID WP_012775363.1
Coordinates 1893233..1893490 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag NQZ96_RS09250 Protein ID WP_002939010.1
Coordinates 1893492..1893752 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ96_RS09230 (NQZ96_09230) 1889702..1891432 - 1731 WP_012775361.1 membrane protein -
NQZ96_RS09235 (NQZ96_09235) 1891797..1892669 - 873 WP_012775362.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
NQZ96_RS09240 (NQZ96_09240) 1892689..1893219 - 531 WP_009910909.1 DUF1697 domain-containing protein -
NQZ96_RS09245 (NQZ96_09245) 1893233..1893490 - 258 WP_012775363.1 Txe/YoeB family addiction module toxin Toxin
NQZ96_RS09250 (NQZ96_09250) 1893492..1893752 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NQZ96_RS09255 (NQZ96_09255) 1893828..1894283 - 456 WP_012028534.1 8-oxo-dGTP diphosphatase -
NQZ96_RS09260 (NQZ96_09260) 1894290..1894619 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin -
NQZ96_RS09265 (NQZ96_09265) 1894609..1894896 - 288 WP_012028535.1 hypothetical protein -
NQZ96_RS09270 (NQZ96_09270) 1894994..1895362 - 369 WP_012775453.1 hypothetical protein -
NQZ96_RS09275 (NQZ96_09275) 1895355..1895924 - 570 WP_012775366.1 ribonuclease M5 -
NQZ96_RS09280 (NQZ96_09280) 1895908..1896690 - 783 WP_012028536.1 TatD family hydrolase -
NQZ96_RS09285 (NQZ96_09285) 1896797..1896934 - 138 WP_002939016.1 50S ribosomal protein L34 -
NQZ96_RS09290 (NQZ96_09290) 1897102..1898097 - 996 WP_012775367.1 RNA-binding cell elongation regulator Jag/EloR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1853463..1896690 43227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10346.81 Da        Isoelectric Point: 7.2737

>T253214 WP_012775363.1 NZ_CP102137:c1893490-1893233 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIQDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR

Download         Length: 258 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT253214 WP_002939010.1 NZ_CP102137:c1893752-1893492 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1SXY6

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References