220440

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1784308..1784827 Replicon chromosome
Accession NZ_CP085088
Organism Streptococcus suis strain Ssuis_MA1

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2K1SXY6
Locus tag LIO33_RS08755 Protein ID WP_012775363.1
Coordinates 1784308..1784565 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag LIO33_RS08760 Protein ID WP_002939010.1
Coordinates 1784567..1784827 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIO33_RS08740 1780777..1782507 - 1731 WP_012775361.1 membrane protein -
LIO33_RS08745 1782872..1783744 - 873 WP_012775362.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
LIO33_RS08750 1783764..1784294 - 531 WP_009910909.1 DUF1697 domain-containing protein -
LIO33_RS08755 1784308..1784565 - 258 WP_012775363.1 Txe/YoeB family addiction module toxin Toxin
LIO33_RS08760 1784567..1784827 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LIO33_RS08765 1784903..1785358 - 456 WP_012028534.1 8-oxo-dGTP diphosphatase -
LIO33_RS08770 1785365..1785694 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin -
LIO33_RS08775 1785684..1785971 - 288 WP_012028535.1 hypothetical protein -
LIO33_RS08780 1786069..1786437 - 369 WP_012775453.1 hypothetical protein -
LIO33_RS08785 1786430..1786999 - 570 WP_012775366.1 ribonuclease M5 -
LIO33_RS08790 1786983..1787765 - 783 WP_012028536.1 TatD family hydrolase -
LIO33_RS08795 1787872..1788009 - 138 WP_002939016.1 50S ribosomal protein L34 -
LIO33_RS08800 1788177..1789172 - 996 WP_012775367.1 RNA-binding cell elongation regulator Jag/EloR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1744538..1787765 43227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10346.81 Da        Isoelectric Point: 7.2737

>T220440 WP_012775363.1 NZ_CP085088:c1784565-1784308 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIQDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR

Download         Length: 258 bp

>T220440 NZ_CP117020:c4844751-4844365 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT220440 WP_002939010.1 NZ_CP085088:c1784827-1784567 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp

>AT220440 NZ_CP117020:c4844375-4844046 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGAAATGAAATAAAACCGAGCGGCCCGGCACTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1SXY6

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References