Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type II Classification (family/domain) relBE/PHD-RelE
Location 2479407..2479924 Replicon chromosome
Accession NC_003923
Organism Staphylococcus aureus subsp. aureus MW2

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MW2329 Protein ID 21284058
Coordinates 2479407..2479673 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MW2330 Protein ID 21284059
Coordinates 2479673..2479924 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MW_RS12580 (MW2324) 2474835..2475362 - 528 WP_000973468.1 GNAT family N-acetyltransferase -
MW_RS12585 (MW2325) 2475606..2476430 - 825 WP_000572040.1 formate/nitrite transporter family protein -
MW_RS12590 (MW2326) 2476647..2476829 - 183 WP_000230294.1 hypothetical protein -
MW_RS12595 (MW2327) 2476913..2477380 - 468 WP_000153344.1 SRPBCC domain-containing protein -
MW_RS12600 (MW2328) 2477566..2479113 - 1548 WP_000727756.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
MW_RS12605 (MW2329) 2479407..2479673 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
MW_RS12610 (MW2330) 2479673..2479924 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MW_RS12615 2480089..2480190 - 102 Protein_2380 hypothetical protein -
MW_RS12620 (MW2331) 2480197..2480796 - 600 WP_000162810.1 DsbA family protein -
MW_RS12625 (MW2332) 2480815..2481177 - 363 WP_000819843.1 DUF4467 domain-containing protein -
MW_RS12630 (MW2333) 2481433..2482683 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
MW_RS12635 (MW2334) 2482780..2483511 - 732 WP_000615458.1 amino acid ABC transporter ATP-binding protein -
MW_RS12640 2483508..2484227 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T613 21284058 NC_003923:c2479673-2479407 [Staphylococcus aureus subsp. aureus MW2]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T613 NC_003923:c2479673-2479407 [Staphylococcus aureus subsp. aureus MW2]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAAATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT613 21284059 NC_003923:c2479924-2479673 [Staphylococcus aureus subsp. aureus MW2]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT613 NC_003923:c2479924-2479673 [Staphylococcus aureus subsp. aureus MW2]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
T2427 Staphylococcus aureus subsp. aureus NCTC 8325

100

100

1
T1074 Staphylococcus aureus subsp. aureus N315

98.864

100

0.989
T4918 Actinobacillus pleuropneumoniae serovar 3 str. JL03

55.294

98.837

0.547
T1043 Escherichia coli str. K-12 substr. MG1655

52.941

100

0.536
T6115 Enterococcus faecium

49.398

97.647

0.482
T6022 Enterococcus faecium

49.398

97.647

0.482
T10021 Lacticaseibacillus rhamnosus 51B

48.193

96.512

0.465
T10020 Lacticaseibacillus rhamnosus strain 24

48.193

96.512

0.465
T6237 Lactobacillus rhamnosus Lc 705

48.193

96.512

0.465
T6143 Lactobacillus rhamnosus ATCC 8530

48.193

96.512

0.465
T6138 Lactobacillus rhamnosus Lc 705

48.193

96.512

0.465
T6122 Streptomyces coelicolor A3(2)

44.706

100

0.452
T728 Streptococcus pneumoniae R6

45.783

98.81

0.452
T6281 Streptococcus suis SC84

44.706

100

0.447
T130 Mycobacterium tuberculosis H37Rv

41.667

98.824

0.412
T310 Pseudomonas putida KT2440

39.535

97.727

0.386
T10072 Edwardsiella tarda EIB202

38.202

100

0.386
T10077 Agrobacterium tumefaciens str. C58

37.079

100

0.375
T10182 Aggregatibacter actinomycetemcomitans D11S 1

34.568

97.59

0.337

Multiple sequence alignment    



Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References

(1) Gul Habib et al. (2018) Bioinformatics and Functional Assessment of Toxin-Antitoxin Systems in Staphylococcus aureus. Toxins 10(11):473. [PubMed:30441856] experimental


experimental experimental literature