Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type II Classification (family/domain) virAT/-
Location 30375..30924 Replicon plasmid pVir
Accession NC_017284
Organism Campylobacter jejuni subsp. jejuni IA3902

Toxin (Protein)


Gene name virT Uniprot ID A0A5T0ZCU7
Locus tag CJSA_RS08780 Protein ID WP_014517465.1
Coordinates 30649..30924 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name virA Uniprot ID A0A5T1T0M3
Locus tag CJSA_RS08775 Protein ID WP_014517464.1
Coordinates 30375..30659 (+) Length 95 a.a.

Genomic Context

CJSA_RS08720CJSA_RS08725CJSA_RS08730CJSA_RS08735CJSA_RS08740CJSA_RS08745CJSA_RS08750CJSA_RS09185CJSA_RS08760CJSA_RS08765CJSA_RS08770CJSA_RS08775CJSA_RS08780CJSA_RS08785CJSA_RS08795CJSA_RS08800CJSA_RS08790
Location: 25632..25976 (345 bp)
Type: Others
Protein ID: WP_011117579.1
Location: 25990..26298 (309 bp)
Type: Others
Protein ID: WP_011117580.1
Location: 26308..26529 (222 bp)
Type: Others
Protein ID: WP_011799395.1
Location: 26542..26937 (396 bp)
Type: Others
Protein ID: WP_011117582.1
Location: 27010..27420 (411 bp)
Type: Others
Protein ID: WP_011117583.1
Location: 27417..27848 (432 bp)
Type: Others
Protein ID: WP_002815407.1
Location: 28056..28241 (186 bp)
Type: Others
Protein ID: WP_004306057.1
Location: 28253..28423 (171 bp)
Type: Others
Protein ID: WP_002815835.1
Location: 28855..29220 (366 bp)
Type: Others
Protein ID: WP_011117585.1
Location: 29257..29592 (336 bp)
Type: Others
Protein ID: WP_011117586.1
Location: 29789..30151 (363 bp)
Type: Others
Protein ID: WP_011117587.1
Location: 30375..30659 (285 bp)
Type: Antitoxin
Protein ID: WP_014517464.1
Location: 30649..30924 (276 bp)
Type: Toxin
Protein ID: WP_014517465.1
Location: 31038..31430 (393 bp)
Type: Others
Protein ID: WP_014517466.1
Location: 34006..34311 (306 bp)
Type: Others
Protein ID: WP_014517469.1
Location: 34311..34553 (243 bp)
Type: Others
Protein ID: WP_011117593.1
Location: 31657..33228 (1572 bp)
Type: Others
Protein ID: WP_014517467.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CJSA_RS08720 (CJSA_pVir0034)25632..25976+345WP_011117579.1hypothetical protein-
CJSA_RS08725 (CJSA_pVir0035)25990..26298+309WP_011117580.1hypothetical protein-
CJSA_RS08730 (CJSA_pVir0036)26308..26529+222WP_011799395.1hypothetical protein-
CJSA_RS08735 (CJSA_pVir0037)26542..26937+396WP_011117582.1hypothetical protein-
CJSA_RS08740 (CJSA_pVir0038)27010..27420+411WP_011117583.1hypothetical protein-
CJSA_RS08745 (CJSA_pVir0039)27417..27848+432WP_002815407.1hypothetical protein-
CJSA_RS08750 (CJSA_pVir0040)28056..28241+186WP_004306057.1hypothetical protein-
CJSA_RS09185 (CJSA_pVir0041)28253..28423+171WP_002815835.1hypothetical protein-
CJSA_RS08760 (CJSA_pVir0042)28855..29220+366WP_011117585.1hypothetical protein-
CJSA_RS08765 (CJSA_pVir0043)29257..29592+336WP_011117586.1hypothetical protein-
CJSA_RS08770 (CJSA_pVir0044)29789..30151+363WP_011117587.1hypothetical protein-
CJSA_RS08775 (CJSA_pVir0045)30375..30659+285WP_014517464.1hypothetical proteinAntitoxin
CJSA_RS08780 (CJSA_pVir0046)30649..30924+276WP_014517465.1type II toxin-antitoxin system YafQ family toxinToxin
CJSA_RS08785 (CJSA_pVir0047)31038..31430+393WP_014517466.1hypothetical protein-
CJSA_RS08790 (CJSA_pVir0048)31657..33228-1572WP_014517467.1relaxase/mobilization nuclease domain-containing protein-
CJSA_RS08795 (CJSA_pVir0050)34006..34311+306WP_014517469.1hypothetical protein-
CJSA_RS08800 (CJSA_pVir0051)34311..34553+243WP_011117593.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideNon-Mobilizable plasmid-virB8 / virB9 / virB10 / virB11 / virD4 / virB4 / Cjp541..3717437174


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10872.64 Da        Isoelectric Point: 10.2009

>T6286 WP_014517465.1 NC_017284:30649-30924 [Campylobacter jejuni subsp. jejuni IA3902]
MQNKYSVTFSKRFKKDFKKINNNDKKILKKIVNKLANDEVLEEKYKDHALKGNYIGFRECHIKPDLLLVYRKNNDILELY
LANLGNHNNIF

Download         Length: 276 bp

>T6286 NC_017284:30649-30924 [Campylobacter jejuni subsp. jejuni IA3902]
ATGCAGAATAAATATAGCGTTACTTTTTCTAAAAGGTTTAAAAAAGATTTTAAAAAAATAAATAATAATGATAAAAAAAT
TTTAAAAAAAATAGTCAATAAACTTGCCAATGATGAAGTATTAGAAGAAAAATACAAAGACCACGCACTAAAAGGAAATT
ATATCGGTTTTAGAGAATGCCACATTAAACCTGATTTGTTATTAGTCTATCGCAAAAATAATGATATTTTAGAATTATAT
TTGGCTAATTTAGGAAATCACAATAATATTTTTTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11082.46 Da        Isoelectric Point: 8.3991

>AT6286 WP_014517464.1 NC_017284:30375-30659 [Campylobacter jejuni subsp. jejuni IA3902]
MFDYSKYENATEKQLIHALTLAEKRAEKLNSQLKENNELFKFLQKKLKNSFNTKKTKKADQRRPELDEAIEDYKNGNVEH
YANVEEAFKALNAE

Download         Length: 285 bp

>AT6286 NC_017284:30375-30659 [Campylobacter jejuni subsp. jejuni IA3902]
ATGTTTGATTATTCTAAATATGAAAATGCTACTGAAAAACAATTAATACACGCTTTGACTTTAGCAGAAAAAAGAGCAGA
GAAACTAAACTCGCAATTAAAAGAGAATAACGAACTTTTTAAATTTTTACAAAAAAAGTTAAAAAATTCTTTTAACACCA
AAAAAACAAAAAAAGCAGATCAAAGAAGACCTGAATTAGATGAAGCGATTGAAGATTATAAAAATGGAAATGTAGAACAT
TATGCCAATGTAGAAGAAGCGTTTAAGGCTTTAAATGCAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
T166Vibrio cholerae O1 biovar El Tor str. N16961

47.778

100

0.483

T6127Helicobacter pylori 26695

47.727

97.778

0.467

T10095Clostridium difficile R20291

45.652

100

0.462

T28Helicobacter pylori 26695

46.988

94.318

0.443

T6256Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222

44.444

98.901

0.44

T10181Aggregatibacter actinomycetemcomitans D11S 1

41.86

97.727

0.409

T10088Helicobacter pylori P12

40.659

100

0.407

T10111Lacticaseibacillus paracasei strain 4366 DinJ and YafQ genes

36.082

100

0.385

T10112Lacticaseibacillus paracasei strain 2333 DinJ and YafQ genes

35.052

100

0.374

T10070Tetragenococcus halophilus NBRC 12172

36.264

100

0.363
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Multiple sequence alignment    


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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A5T0ZCU7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A5T1T0M3

References

(1) Zhangqi Shen et al. (2016) Identification and functional analysis of two toxin-antitoxin systems in Campylobacter jejuni. Molecular Microbiology 101(6):909-23. [PubMed:27291507] experimental


experimental experimental literature