6286

Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type II Classification (family/domain) virAT/-
Location 30375..30924 Replicon plasmid pVir
Accession NC_017284
Organism Campylobacter jejuni subsp. jejuni IA3902

Toxin (Protein)


Gene name virT Uniprot ID A0A5T0ZCU7
Locus tag CJSA_RS08780 Protein ID WP_014517465.1
Coordinates 30649..30924 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name virA Uniprot ID A0A5T1T0M3
Locus tag CJSA_RS08775 Protein ID WP_014517464.1
Coordinates 30375..30659 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CJSA_RS08720 (CJSA_pVir0034) 25632..25976 + 345 WP_011117579.1 hypothetical protein -
CJSA_RS08725 (CJSA_pVir0035) 25990..26298 + 309 WP_011117580.1 hypothetical protein -
CJSA_RS08730 (CJSA_pVir0036) 26308..26529 + 222 WP_011799395.1 hypothetical protein -
CJSA_RS08735 (CJSA_pVir0037) 26542..26937 + 396 WP_011117582.1 hypothetical protein -
CJSA_RS08740 (CJSA_pVir0038) 27010..27420 + 411 WP_011117583.1 hypothetical protein -
CJSA_RS08745 (CJSA_pVir0039) 27417..27848 + 432 WP_002815407.1 hypothetical protein -
CJSA_RS08750 (CJSA_pVir0040) 28056..28241 + 186 WP_004306057.1 hypothetical protein -
CJSA_RS09185 (CJSA_pVir0041) 28253..28423 + 171 WP_002815835.1 hypothetical protein -
CJSA_RS08760 (CJSA_pVir0042) 28855..29220 + 366 WP_011117585.1 hypothetical protein -
CJSA_RS08765 (CJSA_pVir0043) 29257..29592 + 336 WP_011117586.1 hypothetical protein -
CJSA_RS08770 (CJSA_pVir0044) 29789..30151 + 363 WP_011117587.1 hypothetical protein -
CJSA_RS08775 (CJSA_pVir0045) 30375..30659 + 285 WP_014517464.1 hypothetical protein Antitoxin
CJSA_RS08780 (CJSA_pVir0046) 30649..30924 + 276 WP_014517465.1 type II toxin-antitoxin system YafQ family toxin Toxin
CJSA_RS08785 (CJSA_pVir0047) 31038..31430 + 393 WP_014517466.1 hypothetical protein -
CJSA_RS08790 (CJSA_pVir0048) 31657..33228 - 1572 WP_014517467.1 relaxase/mobilization nuclease domain-containing protein -
CJSA_RS08795 (CJSA_pVir0050) 34006..34311 + 306 WP_014517469.1 hypothetical protein -
CJSA_RS08800 (CJSA_pVir0051) 34311..34553 + 243 WP_011117593.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Non-Mobilizable plasmid - virB8 / virB9 / virB10 / virB11 / virD4 / virB4 / Cjp54 1..37174 37174


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10872.64 Da        Isoelectric Point: 10.2009

>T6286 WP_014517465.1 NC_017284:30649-30924 [Campylobacter jejuni subsp. jejuni IA3902]
MQNKYSVTFSKRFKKDFKKINNNDKKILKKIVNKLANDEVLEEKYKDHALKGNYIGFRECHIKPDLLLVYRKNNDILELY
LANLGNHNNIF

Download         Length: 276 bp

>T6286 NC_017284:30649-30924 [Campylobacter jejuni subsp. jejuni IA3902]
ATGCAGAATAAATATAGCGTTACTTTTTCTAAAAGGTTTAAAAAAGATTTTAAAAAAATAAATAATAATGATAAAAAAAT
TTTAAAAAAAATAGTCAATAAACTTGCCAATGATGAAGTATTAGAAGAAAAATACAAAGACCACGCACTAAAAGGAAATT
ATATCGGTTTTAGAGAATGCCACATTAAACCTGATTTGTTATTAGTCTATCGCAAAAATAATGATATTTTAGAATTATAT
TTGGCTAATTTAGGAAATCACAATAATATTTTTTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11082.46 Da        Isoelectric Point: 8.3991

>AT6286 WP_014517464.1 NC_017284:30375-30659 [Campylobacter jejuni subsp. jejuni IA3902]
MFDYSKYENATEKQLIHALTLAEKRAEKLNSQLKENNELFKFLQKKLKNSFNTKKTKKADQRRPELDEAIEDYKNGNVEH
YANVEEAFKALNAE

Download         Length: 285 bp

>AT6286 NC_017284:30375-30659 [Campylobacter jejuni subsp. jejuni IA3902]
ATGTTTGATTATTCTAAATATGAAAATGCTACTGAAAAACAATTAATACACGCTTTGACTTTAGCAGAAAAAAGAGCAGA
GAAACTAAACTCGCAATTAAAAGAGAATAACGAACTTTTTAAATTTTTACAAAAAAAGTTAAAAAATTCTTTTAACACCA
AAAAAACAAAAAAAGCAGATCAAAGAAGACCTGAATTAGATGAAGCGATTGAAGATTATAAAAATGGAAATGTAGAACAT
TATGCCAATGTAGAAGAAGCGTTTAAGGCTTTAAATGCAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5T0ZCU7

Antitoxin

Source ID Structure
AlphaFold DB A0A5T1T0M3

References

(1) Zhangqi Shen et al. (2016) Identification and functional analysis of two toxin-antitoxin systems in Campylobacter jejuni. Molecular Microbiology 101(6):909-23. [PubMed:27291507] experimental


experimental experimental literature