Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type I Classification (family/domain) cjpT-cjrA/-
Location 30634..31117 Replicon plasmid pVir
Accession NC_008770
Organism Campylobacter jejuni subsp. jejuni 81-176

Toxin (Protein)


Gene name cjpT Uniprot ID Q8GJA8
Locus tag CJJ81176_pVir0047 Protein ID WP_011117588.1
Coordinates 30634..31038 (+) Length 135 a.a.

Antitoxin (RNA)


Gene name cjrA
Locus tag CJJ81176_pVir0047a
Coordinates 31040..31117 (-)

Genomic Context

CJJ81176_RS08775CJJ81176_RS08780CJJ81176_RS08785CJJ81176_RS08795CJJ81176_RS08800CJJ81176_RS08805CJJ81176_RS09115CJJ81176_RS08815CJJ81176_RS08820CJJ81176_RS08825CJJ81176_RS08830CJJ81176_RS08835CJJ81176_RS08845CJJ81176_RS08850CJJ81176_pVir0047a-CJJ81176_RS08840
Location: 25704..26048 (345 bp)
Type: Others
Protein ID: WP_011117579.1
Location: 26062..26370 (309 bp)
Type: Others
Protein ID: WP_011117580.1
Location: 26380..26601 (222 bp)
Type: Others
Protein ID: WP_011799395.1
Location: 27082..27492 (411 bp)
Type: Others
Protein ID: WP_011117583.1
Location: 27489..27920 (432 bp)
Type: Others
Protein ID: WP_002815407.1
Location: 28128..28313 (186 bp)
Type: Others
Protein ID: WP_004306057.1
Location: 28325..28495 (171 bp)
Type: Others
Protein ID: WP_002815835.1
Location: 29105..29470 (366 bp)
Type: Others
Protein ID: WP_011117585.1
Location: 29507..29842 (336 bp)
Type: Others
Protein ID: WP_011117586.1
Location: 30039..30401 (363 bp)
Type: Others
Protein ID: WP_011117587.1
Location: 30634..31038 (405 bp)
Type: Toxin
Protein ID: WP_011117588.1
Location: 31284..31676 (393 bp)
Type: Others
Protein ID: WP_011117589.1
Location: 34305..34610 (306 bp)
Type: Others
Protein ID: WP_011799398.1
Location: 34610..34852 (243 bp)
Type: Others
Protein ID: WP_011117593.1
Location: 31040..31117 (78 bp)
Type: Antitoxin
Protein ID: -
Location: 31903..33474 (1572 bp)
Type: Others
Protein ID: WP_011799396.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CJJ81176_RS08775 (CJJ81176_pVir0035)25704..26048+345WP_011117579.1hypothetical protein-
CJJ81176_RS08780 (CJJ81176_pVir0036)26062..26370+309WP_011117580.1hypothetical protein-
CJJ81176_RS08785 (CJJ81176_pVir0037)26380..26601+222WP_011799395.1hypothetical protein-
CJJ81176_RS08795 (CJJ81176_pVir0039)27082..27492+411WP_011117583.1hypothetical protein-
CJJ81176_RS08800 (CJJ81176_pVir0040)27489..27920+432WP_002815407.1hypothetical protein-
CJJ81176_RS08805 (CJJ81176_pVir0041)28128..28313+186WP_004306057.1hypothetical protein-
CJJ81176_RS09115 (CJJ81176_pVir0042)28325..28495+171WP_002815835.1hypothetical protein-
CJJ81176_RS08815 (CJJ81176_pVir0044)29105..29470+366WP_011117585.1hypothetical protein-
CJJ81176_RS08820 (CJJ81176_pVir0045)29507..29842+336WP_011117586.1hypothetical protein-
CJJ81176_RS08825 (CJJ81176_pVir0046)30039..30401+363WP_011117587.1hypothetical protein-
CJJ81176_RS08830 (CJJ81176_pVir0047)30634..31038+405WP_011117588.1type II toxin-antitoxin system PemK/MazF family toxinToxin
-31040..31117-78--Antitoxin
CJJ81176_RS08835 (CJJ81176_pVir0048)31284..31676+393WP_011117589.1hypothetical protein-
CJJ81176_RS08840 (CJJ81176_pVir0049)31903..33474-1572WP_011799396.1relaxase/mobilization nuclease domain-containing protein-
CJJ81176_RS08845 (CJJ81176_pVir0051)34305..34610+306WP_011799398.1hypothetical protein-
CJJ81176_RS08850 (CJJ81176_pVir0052)34610..34852+243WP_011117593.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideNon-Mobilizable plasmid-virB8 / virB9 / virB10 / virB11 / virD4 / virB4 / Cjp541..3747337473


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(28-130)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15715.47 Da        Isoelectric Point: 10.5279

>T6287 WP_011117588.1 NC_008770:30634-31038 [Campylobacter jejuni subsp. jejuni 81-176]
MQNEDLKFDEWNEVKKHIEKEKNKIVKKQKIYWIKIGKNIGSEIFGKGRVFARPVLVINVFYNGLFLGVPLSSKTKNKSG
KLYYKFTDEKGNSQVALLGQMKIFDNKRKITFESNVKNEDFILIKEKIKKNIID

Download         Length: 405 bp

>T6287 NC_008770:30634-31038 [Campylobacter jejuni subsp. jejuni 81-176]
ATGCAAAATGAAGATTTGAAATTTGATGAATGGAATGAAGTTAAAAAACATATTGAAAAAGAAAAAAATAAAATTGTTAA
AAAACAAAAAATATATTGGATTAAAATTGGTAAAAATATAGGGAGTGAGATTTTTGGCAAAGGAAGGGTTTTTGCACGCC
CTGTTTTAGTAATTAATGTATTTTATAATGGTTTGTTTTTAGGAGTTCCTTTAAGTTCAAAAACAAAAAATAAAAGTGGT
AAGCTATATTATAAATTCACAGATGAAAAAGGAAATTCGCAAGTTGCACTTTTGGGGCAAATGAAAATTTTTGATAATAA
GAGAAAAATAACATTTGAAAGCAATGTTAAAAATGAAGATTTTATTTTAATAAAAGAAAAAATAAAAAAGAATATTATAG
ATTAA

Antitoxin


Download         Length: 78 bp

>AT6287 NC_008770:c31117-31040 [Campylobacter jejuni subsp. jejuni 81-176]
TTGACTTCCTAAATGAAAGTTTAGCGAAGAATTGGCTTATCTTTTAGATAGGTTGCCCCGTCATAGAGCGGGGATAAT

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A3Z8TNU2

Antitoxin

Download structure file

References

(1) Zhangqi Shen et al. (2016) Identification and functional analysis of two toxin-antitoxin systems in Campylobacter jejuni. Molecular Microbiology 101(6):909-23. [PubMed:27291507] experimental


experimental experimental literature