Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/- |
| Location | 1109369..1109919 | Replicon | chromosome |
| Accession | NC_013416 | ||
| Organism | Aggregatibacter actinomycetemcomitans D11S 1 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | X2JVL6 |
| Locus tag | D11S_RS05705 | Protein ID | WP_005545988.1 |
| Coordinates | 1109369..1109635 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | D11S_RS05710 | Protein ID | WP_005545990.1 |
| Coordinates | 1109647..1109919 (-) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| D11S_RS05685 (D11S_1190) | 1104993..1106231 | + | 1239 | WP_005545980.1 | phage antirepressor N-terminal domain-containing protein | - |
| D11S_RS05690 (D11S_1191) | 1106231..1106842 | + | 612 | WP_005590093.1 | DUF4376 domain-containing protein | - |
| D11S_RS05695 | 1106839..1107597 | - | 759 | WP_005545985.1 | DUF4102 domain-containing protein | - |
| D11S_RS05700 (D11S_1193) | 1107778..1109337 | - | 1560 | WP_005545986.1 | glutamine-hydrolyzing GMP synthase | - |
| D11S_RS05705 (D11S_1194) | 1109369..1109635 | - | 267 | WP_005545988.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| D11S_RS05710 (D11S_1195) | 1109647..1109919 | - | 273 | WP_005545990.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| D11S_RS05720 (D11S_1197) | 1110174..1111526 | - | 1353 | WP_005545994.1 | anaerobic C4-dicarboxylate transporter DcuC | - |
| D11S_RS05730 (D11S_1199) | 1111965..1112420 | + | 456 | WP_005545995.1 | ribosome maturation factor RimP | - |
| D11S_RS05735 (D11S_1200) | 1112444..1113940 | + | 1497 | WP_005545997.1 | transcription termination factor NusA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10516.05 Da Isoelectric Point: 7.2393
>T10181 WP_005545988.1 NC_013416:c1109635-1109369 [Aggregatibacter actinomycetemcomitans D11S-1]
MDYVLSKEYKRDLKKLPVEIQSGPEYAEVLYCLFNQKSLPERYKDHALQGNWQGFRDCHIKNDLILIYKIEADTLYFARL
NSHSEVFK
MDYVLSKEYKRDLKKLPVEIQSGPEYAEVLYCLFNQKSLPERYKDHALQGNWQGFRDCHIKNDLILIYKIEADTLYFARL
NSHSEVFK
Download Length: 267 bp
>T10181 NC_013416:c1109635-1109369 [Aggregatibacter actinomycetemcomitans D11S-1]
ATGGATTACGTTTTATCAAAAGAATATAAACGGGACTTAAAAAAACTTCCGGTCGAAATTCAATCCGGTCCGGAATATGC
AGAGGTTTTATATTGCCTGTTCAATCAAAAATCCCTACCCGAACGATATAAAGATCATGCTTTGCAAGGAAATTGGCAGG
GATTTCGAGATTGCCACATCAAAAATGATCTCATTTTAATTTACAAAATAGAAGCAGACACCCTCTATTTTGCAAGGCTA
AATTCTCACTCGGAAGTGTTTAAATAA
ATGGATTACGTTTTATCAAAAGAATATAAACGGGACTTAAAAAAACTTCCGGTCGAAATTCAATCCGGTCCGGAATATGC
AGAGGTTTTATATTGCCTGTTCAATCAAAAATCCCTACCCGAACGATATAAAGATCATGCTTTGCAAGGAAATTGGCAGG
GATTTCGAGATTGCCACATCAAAAATGATCTCATTTTAATTTACAAAATAGAAGCAGACACCCTCTATTTTGCAAGGCTA
AATTCTCACTCGGAAGTGTTTAAATAA
Antitoxin
Download Length: 91 a.a. Molecular weight: 10165.56 Da Isoelectric Point: 6.2633
>AT10181 WP_005545990.1 NC_013416:c1109919-1109647 [Aggregatibacter actinomycetemcomitans D11S-1]
MLDSAVNFRTQADIKEQAFNVIKSYGLTPAQVLNMFLTQIAKTNTIPLSLDYQPNTKTANAINELMSGKGERFSVDSFDE
FQQKMRDLSK
MLDSAVNFRTQADIKEQAFNVIKSYGLTPAQVLNMFLTQIAKTNTIPLSLDYQPNTKTANAINELMSGKGERFSVDSFDE
FQQKMRDLSK
Download Length: 273 bp
>AT10181 NC_013416:c1109919-1109647 [Aggregatibacter actinomycetemcomitans D11S-1]
ATGTTAGATAGCGCAGTGAATTTCCGTACTCAAGCCGACATCAAAGAGCAAGCGTTTAACGTCATTAAAAGCTATGGCTT
AACGCCCGCTCAGGTGTTAAATATGTTTTTGACCCAAATTGCCAAAACCAACACAATTCCGCTCAGTTTGGATTATCAGC
CGAATACAAAAACAGCTAATGCAATCAATGAATTAATGAGCGGAAAAGGGGAAAGATTTAGCGTAGATTCCTTTGATGAA
TTTCAACAAAAAATGCGTGATTTAAGCAAATAA
ATGTTAGATAGCGCAGTGAATTTCCGTACTCAAGCCGACATCAAAGAGCAAGCGTTTAACGTCATTAAAAGCTATGGCTT
AACGCCCGCTCAGGTGTTAAATATGTTTTTGACCCAAATTGCCAAAACCAACACAATTCCGCTCAGTTTGGATTATCAGC
CGAATACAAAAACAGCTAATGCAATCAATGAATTAATGAGCGGAAAAGGGGAAAGATTTAGCGTAGATTCCTTTGATGAA
TTTCAACAAAAAATGCGTGATTTAAGCAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| T166 | Vibrio cholerae O1 biovar El Tor str. N16961 |
44.578 |
94.318 |
0.42 |
| T6286 | Campylobacter jejuni subsp. jejuni IA3902 |
41.86 |
97.727 |
0.409 |
| T6127 | Helicobacter pylori 26695 |
40.23 |
98.864 |
0.398 |
| T10095 | Clostridium difficile R20291 |
39.286 |
95.455 |
0.375 |
| T28 | Helicobacter pylori 26695 |
39.759 |
94.318 |
0.375 |
| T10088 | Helicobacter pylori P12 |
44.928 |
78.409 |
0.352 |
| T10111 | Lacticaseibacillus paracasei strain 4366 DinJ and YafQ genes |
31.959 |
100 |
0.352 |
| T6256 | Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 |
36.905 |
95.455 |
0.352 |
| T10112 | Lacticaseibacillus paracasei strain 2333 DinJ and YafQ genes |
30.928 |
100 |
0.341 |
Multiple sequence alignment
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| AT6257 | Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 |
35.714 |
94.382 |
0.337 |
| AT6289 | Bifidobacterium longum subsp. longum JDM301 |
34.524 |
94.382 |
0.326 |
Multiple sequence alignment
References
(1) B Schneider et al. (2018) Identification and functional characterization of type II toxin/antitoxin systems in Aggregatibacter actinomycetemcomitans. Molecular Oral Microbiology 33(3):224-233. [PubMed:29319934]