Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type II Classification (family/domain) relBE/-
Location 1109369..1109919 Replicon chromosome
Accession NC_013416
Organism Aggregatibacter actinomycetemcomitans D11S 1

Toxin (Protein)


Gene name relE Uniprot ID X2JVL6
Locus tag D11S_RS05705 Protein ID WP_005545988.1
Coordinates 1109369..1109635 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag D11S_RS05710 Protein ID WP_005545990.1
Coordinates 1109647..1109919 (-) Length 91 a.a.

Genomic Context

D11S_RS05685D11S_RS05690D11S_RS05730D11S_RS05735D11S_RS05695D11S_RS05700D11S_RS05705D11S_RS05710D11S_RS05720
Location: 1104993..1106231 (1239 bp)
Type: Others
Protein ID: WP_005545980.1
Location: 1106231..1106842 (612 bp)
Type: Others
Protein ID: WP_005590093.1
Location: 1111965..1112420 (456 bp)
Type: Others
Protein ID: WP_005545995.1
Location: 1112444..1113940 (1497 bp)
Type: Others
Protein ID: WP_005545997.1
Location: 1106839..1107597 (759 bp)
Type: Others
Protein ID: WP_005545985.1
Location: 1107778..1109337 (1560 bp)
Type: Others
Protein ID: WP_005545986.1
Location: 1109369..1109635 (267 bp)
Type: Toxin
Protein ID: WP_005545988.1
Location: 1109647..1109919 (273 bp)
Type: Antitoxin
Protein ID: WP_005545990.1
Location: 1110174..1111526 (1353 bp)
Type: Others
Protein ID: WP_005545994.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
D11S_RS05685 (D11S_1190)1104993..1106231+1239WP_005545980.1phage antirepressor N-terminal domain-containing protein-
D11S_RS05690 (D11S_1191)1106231..1106842+612WP_005590093.1DUF4376 domain-containing protein-
D11S_RS056951106839..1107597-759WP_005545985.1DUF4102 domain-containing protein-
D11S_RS05700 (D11S_1193)1107778..1109337-1560WP_005545986.1glutamine-hydrolyzing GMP synthase-
D11S_RS05705 (D11S_1194)1109369..1109635-267WP_005545988.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
D11S_RS05710 (D11S_1195)1109647..1109919-273WP_005545990.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
D11S_RS05720 (D11S_1197)1110174..1111526-1353WP_005545994.1anaerobic C4-dicarboxylate transporter DcuC-
D11S_RS05730 (D11S_1199)1111965..1112420+456WP_005545995.1ribosome maturation factor RimP-
D11S_RS05735 (D11S_1200)1112444..1113940+1497WP_005545997.1transcription termination factor NusA-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-88)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-85)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10516.05 Da        Isoelectric Point: 7.2393

>T10181 WP_005545988.1 NC_013416:c1109635-1109369 [Aggregatibacter actinomycetemcomitans D11S-1]
MDYVLSKEYKRDLKKLPVEIQSGPEYAEVLYCLFNQKSLPERYKDHALQGNWQGFRDCHIKNDLILIYKIEADTLYFARL
NSHSEVFK

Download         Length: 267 bp

>T10181 NC_013416:c1109635-1109369 [Aggregatibacter actinomycetemcomitans D11S-1]
ATGGATTACGTTTTATCAAAAGAATATAAACGGGACTTAAAAAAACTTCCGGTCGAAATTCAATCCGGTCCGGAATATGC
AGAGGTTTTATATTGCCTGTTCAATCAAAAATCCCTACCCGAACGATATAAAGATCATGCTTTGCAAGGAAATTGGCAGG
GATTTCGAGATTGCCACATCAAAAATGATCTCATTTTAATTTACAAAATAGAAGCAGACACCCTCTATTTTGCAAGGCTA
AATTCTCACTCGGAAGTGTTTAAATAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10165.56 Da        Isoelectric Point: 6.2633

>AT10181 WP_005545990.1 NC_013416:c1109919-1109647 [Aggregatibacter actinomycetemcomitans D11S-1]
MLDSAVNFRTQADIKEQAFNVIKSYGLTPAQVLNMFLTQIAKTNTIPLSLDYQPNTKTANAINELMSGKGERFSVDSFDE
FQQKMRDLSK

Download         Length: 273 bp

>AT10181 NC_013416:c1109919-1109647 [Aggregatibacter actinomycetemcomitans D11S-1]
ATGTTAGATAGCGCAGTGAATTTCCGTACTCAAGCCGACATCAAAGAGCAAGCGTTTAACGTCATTAAAAGCTATGGCTT
AACGCCCGCTCAGGTGTTAAATATGTTTTTGACCCAAATTGCCAAAACCAACACAATTCCGCTCAGTTTGGATTATCAGC
CGAATACAAAAACAGCTAATGCAATCAATGAATTAATGAGCGGAAAAGGGGAAAGATTTAGCGTAGATTCCTTTGATGAA
TTTCAACAAAAAATGCGTGATTTAAGCAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
T166Vibrio cholerae O1 biovar El Tor str. N16961

44.578

94.318

0.42

T6286Campylobacter jejuni subsp. jejuni IA3902

41.86

97.727

0.409

T6127Helicobacter pylori 26695

40.23

98.864

0.398

T10095Clostridium difficile R20291

39.286

95.455

0.375

T28Helicobacter pylori 26695

39.759

94.318

0.375

T10088Helicobacter pylori P12

44.928

78.409

0.352

T10111Lacticaseibacillus paracasei strain 4366 DinJ and YafQ genes

31.959

100

0.352

T6256Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222

36.905

95.455

0.352

T10112Lacticaseibacillus paracasei strain 2333 DinJ and YafQ genes

30.928

100

0.341
Showing 1 to 9 of 9 rows

Multiple sequence alignment    


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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
AT6257Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222

35.714

94.382

0.337

AT6289Bifidobacterium longum subsp. longum JDM301

34.524

94.382

0.326
Showing 1 to 2 of 2 rows

Multiple sequence alignment    




Structures

Toxin

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Source
ID
Structure
AlphaFold DBX2JVL6

Antitoxin

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Source
ID
Structure
No matching records found

References

(1) B Schneider et al. (2018) Identification and functional characterization of type II toxin/antitoxin systems in Aggregatibacter actinomycetemcomitans. Molecular Oral Microbiology 33(3):224-233. [PubMed:29319934] experimental


experimental experimental literature