Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/-
Location 2750335..2751134 Replicon chromosome
Accession NC_020518
Organism Escherichia coli str. K-12 substr. MDS42

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag ECMDS42_RS13295 Protein ID WP_000347273.1
Coordinates 2750670..2751134 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag ECMDS42_RS13290 Protein ID WP_001307405.1
Coordinates 2750335..2750670 (+) Length 112 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECMDS42_RS13275 (ECMDS42_2593) 2746120..2746890 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
ECMDS42_RS13280 (ECMDS42_2594) 2746906..2748240 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
ECMDS42_RS13285 (ECMDS42_2595) 2748615..2750186 + 1572 WP_001273753.1 galactarate dehydratase -
ECMDS42_RS13290 (ECMDS42_2596) 2750335..2750670 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
ECMDS42_RS13295 (ECMDS42_2597) 2750670..2751134 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
ECMDS42_RS13300 (ECMDS42_2598) 2751189..2751998 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
ECMDS42_RS13305 (ECMDS42_2599) 2752247..2753527 + 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
ECMDS42_RS13310 (ECMDS42_2600) 2753550..2754023 + 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
ECMDS42_RS13315 (ECMDS42_2601) 2754034..2754405 + 372 Protein_2530 PTS N-acetylgalactosamine transporter subunit IIC -
ECMDS42_RS13320 (ECMDS42_2602) 2754401..2754958 + 558 Protein_2531 amidohydrolase family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2741187..2751134 9947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-150)

Antitoxin

(14-110)


Sequences


Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T29016 WP_000347273.1 NC_020518:2750670-2751134 [Escherichia coli str. K-12 substr. MDS42]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T29016 NC_020518:2750670-2751134 [Escherichia coli str. K-12 substr. MDS42]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT29016 WP_001307405.1 NC_020518:2750335-2750670 [Escherichia coli str. K-12 substr. MDS42]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT29016 NC_020518:2750335-2750670 [Escherichia coli str. K-12 substr. MDS42]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB V0SSH7


Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References