51022

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 561345..562144 Replicon chromosome
Accession NZ_CP010169
Organism Escherichia coli strain H5

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag RG47_RS02925 Protein ID WP_073464266.1
Coordinates 561680..562144 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID D6JF08
Locus tag RG47_RS02920 Protein ID WP_001308975.1
Coordinates 561345..561680 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG47_RS02905 557130..557900 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
RG47_RS02910 557916..559250 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
RG47_RS02915 559625..561196 + 1572 WP_032181387.1 galactarate dehydratase -
RG47_RS02920 561345..561680 + 336 WP_001308975.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
RG47_RS02925 561680..562144 + 465 WP_073464266.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
RG47_RS02930 562199..563008 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
RG47_RS02940 563257..564537 + 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
RG47_RS02945 564560..565033 + 474 WP_073464263.1 PTS N-acetylgalactosamine transporter subunit IIB -
RG47_RS02950 565044..565823 + 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
RG47_RS02955 565813..566691 + 879 WP_073464261.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
RG47_RS02960 566709..567143 + 435 WP_000948824.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 550576..562144 11568


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17754.10 Da        Isoelectric Point: 9.4944

>T51022 WP_073464266.1 NZ_CP010169:561680-562144 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEENITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

>T51022 NZ_CP010169:561680-562144 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGAATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12343.97 Da        Isoelectric Point: 4.8616

>AT51022 WP_001308975.1 NZ_CP010169:561345-561680 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT51022 NZ_CP010169:561345-561680 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB D6JF08

References