23871

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3162172..3162971 Replicon chromosome
Accession NC_012759
Organism Escherichia coli BW2952

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag BWG_RS15685 Protein ID WP_000347273.1
Coordinates 3162507..3162971 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag BWG_RS15680 Protein ID WP_001307405.1
Coordinates 3162172..3162507 (+) Length 112 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWG_RS15665 (BWG_2832) 3157957..3158727 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
BWG_RS15670 (BWG_2833) 3158743..3160077 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
BWG_RS15675 (BWG_2834) 3160452..3162023 + 1572 WP_001273753.1 galactarate dehydratase -
BWG_RS15680 (BWG_2835) 3162172..3162507 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
BWG_RS15685 (BWG_2836) 3162507..3162971 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
BWG_RS15690 (BWG_2837) 3163026..3163835 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
BWG_RS15695 (BWG_2838) 3164084..3165364 + 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
BWG_RS15700 (BWG_2839) 3165387..3165860 + 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
BWG_RS15705 3165871..3166242 + 372 Protein_2995 PTS sugar transporter subunit IIC -
BWG_RS15710 3166238..3166795 + 558 Protein_2996 amidohydrolase family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3153024..3162971 9947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-150)

Antitoxin

(14-110)


Sequences


Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T23871 WP_000347273.1 NC_012759:3162507-3162971 [Escherichia coli BW2952]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T23871 NC_012759:3162507-3162971 [Escherichia coli BW2952]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT23871 WP_001307405.1 NC_012759:3162172-3162507 [Escherichia coli BW2952]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT23871 NC_012759:3162172-3162507 [Escherichia coli BW2952]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB V0SSH7


Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References