293279

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3646210..3647009 Replicon chromosome
Accession NZ_LT601384
Organism Escherichia coli isolate NCTC86EC

Toxin (Protein)


Gene name yhaV Uniprot ID A0A0A6SPA6
Locus tag NCTC86EC_RS17955 Protein ID WP_000347275.1
Coordinates 3646545..3647009 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag NCTC86EC_RS17950 Protein ID WP_001307405.1
Coordinates 3646210..3646545 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NCTC86EC_RS17935 3641995..3642765 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
NCTC86EC_RS17940 3642781..3644115 - 1335 WP_066008923.1 galactarate/glucarate/glycerate transporter GarP -
NCTC86EC_RS17945 3644490..3646061 + 1572 WP_001273753.1 galactarate dehydratase -
NCTC86EC_RS17950 3646210..3646545 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NCTC86EC_RS17955 3646545..3647009 + 465 WP_000347275.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NCTC86EC_RS17960 3647064..3647873 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
NCTC86EC_RS17965 3648122..3649402 + 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
NCTC86EC_RS17970 3649425..3649898 + 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
NCTC86EC_RS17975 3649909..3650688 + 780 WP_000406209.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
NCTC86EC_RS17980 3650678..3651556 + 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
NCTC86EC_RS17985 3651574..3652008 + 435 WP_000948824.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3637062..3647009 9947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17820.29 Da        Isoelectric Point: 9.8492

>T293279 WP_000347275.1 NZ_LT601384:3646545-3647009 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKVPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT293279 WP_001307405.1 NZ_LT601384:3646210-3646545 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6SPA6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References