22436

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3325622..3326421 Replicon chromosome
Accession NC_009800
Organism Escherichia coli HS

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag ECHS_RS16355 Protein ID WP_000347251.1
Coordinates 3325957..3326421 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag ECHS_RS16350 Protein ID WP_001307405.1
Coordinates 3325622..3325957 (+) Length 112 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECHS_RS16335 (EcHS_A3315) 3321407..3322177 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
ECHS_RS16340 (EcHS_A3316) 3322193..3323527 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
ECHS_RS16345 (EcHS_A3318) 3323902..3325473 + 1572 WP_001273782.1 galactarate dehydratase -
ECHS_RS16350 (EcHS_A3319) 3325622..3325957 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
ECHS_RS16355 (EcHS_A3320) 3325957..3326421 + 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
ECHS_RS16360 (EcHS_A3321) 3326476..3327285 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
ECHS_RS16365 (EcHS_A3322) 3327534..3328814 + 1281 WP_000681905.1 tagatose-bisphosphate aldolase subunit KbaZ -
ECHS_RS16370 (EcHS_A3323) 3328837..3329310 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
ECHS_RS16375 (EcHS_A3324) 3329321..3330100 + 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
ECHS_RS16380 (EcHS_A3325) 3330090..3330968 + 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
ECHS_RS16385 (EcHS_A3326) 3330986..3331420 + 435 WP_000948824.1 PTS sugar transporter subunit IIA -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3314965..3326421 11456


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-150)

Antitoxin

(14-110)


Sequences


Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T22436 WP_000347251.1 NC_009800:3325957-3326421 [Escherichia coli HS]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

>T22436 NC_009800:3325957-3326421 [Escherichia coli HS]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT22436 WP_001307405.1 NC_009800:3325622-3325957 [Escherichia coli HS]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT22436 NC_009800:3325622-3325957 [Escherichia coli HS]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGTCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A829CJ20


Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References