87293

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 250390..251189 Replicon chromosome
Accession NZ_CP024256
Organism Escherichia coli strain ATCC 43886

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag CS032_RS02760 Protein ID WP_000347273.1
Coordinates 250725..251189 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID -
Locus tag CS032_RS02755 Protein ID WP_005762317.1
Coordinates 250390..250725 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CS032_RS02740 246190..246960 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
CS032_RS02745 246976..248295 - 1320 WP_001735763.1 galactarate/glucarate/glycerate transporter GarP -
CS032_RS02750 248670..250241 + 1572 WP_001273753.1 galactarate dehydratase -
CS032_RS02755 250390..250725 + 336 WP_005762317.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
CS032_RS02760 250725..251189 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
CS032_RS02765 251244..252053 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
CS032_RS02775 252302..253582 + 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
CS032_RS02780 253605..254078 + 474 WP_001735764.1 PTS N-acetylgalactosamine transporter subunit IIB -
CS032_RS02785 254089..254868 + 780 WP_000406208.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
CS032_RS02790 254858..255736 + 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
CS032_RS02795 255754..256188 + 435 WP_000948842.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 241370..251189 9819


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T87293 WP_000347273.1 NZ_CP024256:250725-251189 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T87293 NZ_CP024256:250725-251189 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12344.91 Da        Isoelectric Point: 4.8616

>AT87293 WP_005762317.1 NZ_CP024256:250390-250725 [Escherichia coli]
MPANARSHAVLTSESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT87293 NZ_CP024256:250390-250725 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCTCTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure

References