58813

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 1041431..1042230 Replicon chromosome
Accession NZ_CP013483
Organism Escherichia coli strain Y5

Toxin (Protein)


Gene name yhaV Uniprot ID A0A0A6SPA6
Locus tag ATO45_RS05155 Protein ID WP_000347275.1
Coordinates 1041431..1041895 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag ATO45_RS05160 Protein ID WP_001307405.1
Coordinates 1041895..1042230 (-) Length 112 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ATO45_RS05125 1036432..1036866 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
ATO45_RS05130 1036884..1037762 - 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
ATO45_RS05135 1037752..1038531 - 780 WP_000406209.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
ATO45_RS05140 1038542..1039015 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
ATO45_RS05145 1039038..1040318 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
ATO45_RS05150 1040567..1041376 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
ATO45_RS05155 1041431..1041895 - 465 WP_000347275.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
ATO45_RS05160 1041895..1042230 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
ATO45_RS05165 1042379..1043950 - 1572 WP_001273752.1 galactarate dehydratase -
ATO45_RS05170 1044325..1045659 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
ATO45_RS05175 1045675..1046445 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1041431..1053105 11674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-150)

Antitoxin

(14-110)


Sequences


Toxin        


Download         Length: 155 a.a.        Molecular weight: 17820.29 Da        Isoelectric Point: 9.8492

>T58813 WP_000347275.1 NZ_CP013483:c1041895-1041431 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKVPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T58813 NZ_CP013483:c1041895-1041431 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGTTCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT58813 WP_001307405.1 NZ_CP013483:c1042230-1041895 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT58813 NZ_CP013483:c1042230-1041895 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0A6SPA6


Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References