267034

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2739396..2740195 Replicon chromosome
Accession NZ_CP114896
Organism Escherichia coli strain CM93

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag O6117_RS13440 Protein ID WP_000347273.1
Coordinates 2739731..2740195 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag O6117_RS13435 Protein ID WP_001307405.1
Coordinates 2739396..2739731 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6117_RS13420 (2735181) 2735181..2735951 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
O6117_RS13425 (2735967) 2735967..2737301 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
O6117_RS13430 (2737676) 2737676..2739247 + 1572 WP_001273753.1 galactarate dehydratase -
O6117_RS13435 (2739396) 2739396..2739731 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
O6117_RS13440 (2739731) 2739731..2740195 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
O6117_RS13445 (2740250) 2740250..2741059 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
O6117_RS13450 (2741308) 2741308..2742588 + 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
O6117_RS13455 (2742611) 2742611..2743084 + 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
O6117_RS13460 (2743095) 2743095..2743466 + 372 Protein_2625 PTS sugar transporter subunit IIC -
O6117_RS13465 (2743462) 2743462..2744019 + 558 Protein_2626 amidohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2730248..2740195 9947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T267034 WP_000347273.1 NZ_CP114896:2739731-2740195 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT267034 WP_001307405.1 NZ_CP114896:2739396-2739731 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References