150553

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 378455..379254 Replicon chromosome
Accession NZ_CP049112
Organism Escherichia coli strain WF5-5-T2

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag G6R06_RS01795 Protein ID WP_000347273.1
Coordinates 378790..379254 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag G6R06_RS01790 Protein ID WP_001307405.1
Coordinates 378455..378790 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6R06_RS01775 (374240) 374240..375010 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
G6R06_RS01780 (375026) 375026..376360 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
G6R06_RS01785 (376735) 376735..378306 + 1572 WP_001273753.1 galactarate dehydratase -
G6R06_RS01790 (378455) 378455..378790 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
G6R06_RS01795 (378790) 378790..379254 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
G6R06_RS01800 (379309) 379309..380118 - 810 WP_103119122.1 aga operon transcriptional regulator AgaR -
G6R06_RS01805 (380367) 380367..381647 + 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
G6R06_RS01810 (381670) 381670..382143 + 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
G6R06_RS01815 (382154) 382154..382525 + 372 Protein_357 PTS sugar transporter subunit IIC -
G6R06_RS01820 (382521) 382521..383078 + 558 Protein_358 amidohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 367766..379254 11488


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T150553 WP_000347273.1 NZ_CP049112:378790-379254 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T150553 NZ_CP064784:c4987075-4986665 [Klebsiella sp. BDA134-6]
GTGGTCCTGTGGCAATCTGATTTACGCATCTCGTGGCGCGCGCAGTGGTTCTCACTGCTGATGCACGGCGTGGTGGCGGC
GCTGGTGCTGGTATTGCCCTGGCCGCTGAGCTATACCCCGCTGTGGCTGATATTGCTGTCGCTGGTAGTGTTCGACTGCG
TACGCAGCCAGCGGCGAATCCACGCCCGTCAGGGTGAAATAAAGCTGCTGATCGACTCGCGTCTGCGCTGGCAAAAGGCA
GAGTGGGATATCATCGGCACGCCGTGGGTAATCAACAGCGGCATGCTGCTGCGCCTGCGGAATACGGAAAACCAACGTAC
CCAGCATTTGTGGGTCGCGGCGGATAGCATGGACGCGGGAGAATGGCGCGACCTGCGTCGGCTAGTGTTACAGAAACCGA
CGCAAGAGTAG

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT150553 WP_001307405.1 NZ_CP049112:378455-378790 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT150553 NZ_CP064784:c4987322-4987056 [Klebsiella sp. BDA134-6]
ATGGACATTAACAATAAAGCCCGCATCCACTGGGCATGTCGTCGAGGTATGCGTGAACTCGATATCTCCATCATGCCGTT
TTTCGAGCATGAGTACGACACGCTAAGCGATGGCGATAAGGCGTTATTCATCCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGTTGATGAATCATGGCGAGCCGGCTGATGCTGAACTGCAGCGGATGGTAAAATTAATTCAGACTCGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References