120230

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3270023..3270822 Replicon chromosome
Accession NZ_CP037857
Organism Escherichia coli BW25113 strain AM187

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag E1A98_RS15985 Protein ID WP_000347273.1
Coordinates 3270358..3270822 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag E1A98_RS15980 Protein ID WP_001307405.1
Coordinates 3270023..3270358 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1A98_RS15965 3265808..3266578 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
E1A98_RS15970 3266594..3267928 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
E1A98_RS15975 3268303..3269874 + 1572 WP_001273753.1 galactarate dehydratase -
E1A98_RS15980 3270023..3270358 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
E1A98_RS15985 3270358..3270822 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
E1A98_RS15990 3270877..3271686 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
E1A98_RS15995 3271935..3273215 + 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
E1A98_RS16000 3273238..3273711 + 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
E1A98_RS16005 3273722..3274093 + 372 Protein_3114 PTS sugar transporter subunit IIC -
E1A98_RS16010 3274089..3274646 + 558 Protein_3115 amidohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3260875..3270822 9947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T120230 WP_000347273.1 NZ_CP037857:3270358-3270822 [Escherichia coli BW25113]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T120230 NZ_CP037857:3270358-3270822 [Escherichia coli BW25113]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT120230 WP_001307405.1 NZ_CP037857:3270023-3270358 [Escherichia coli BW25113]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT120230 NZ_CP037857:3270023-3270358 [Escherichia coli BW25113]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References