174136

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3270361..3271160 Replicon chromosome
Accession NZ_CP062250
Organism Escherichia coli strain AML002_par

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag IHN45_RS15870 Protein ID WP_000347273.1
Coordinates 3270696..3271160 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag IHN45_RS15865 Protein ID WP_001307405.1
Coordinates 3270361..3270696 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHN45_RS15850 3266146..3266916 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
IHN45_RS15855 3266932..3268266 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
IHN45_RS15860 3268641..3270212 + 1572 WP_001273753.1 galactarate dehydratase -
IHN45_RS15865 3270361..3270696 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
IHN45_RS15870 3270696..3271160 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
IHN45_RS15875 3271215..3272024 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
IHN45_RS15880 3272273..3273553 + 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
IHN45_RS15885 3273576..3274049 + 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
IHN45_RS15890 3274060..3274431 + 372 Protein_3103 PTS sugar transporter subunit IIC -
IHN45_RS15895 3274427..3274984 + 558 Protein_3104 amidohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3261213..3271160 9947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T174136 WP_000347273.1 NZ_CP062250:3270696-3271160 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T174136 NZ_CP080553:c2252865-2252656 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT174136 WP_001307405.1 NZ_CP062250:3270361-3270696 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT174136 NZ_CP080553:c2253170-2252877 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References