276743

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 4267408..4268207 Replicon chromosome
Accession NZ_CP122318
Organism Escherichia coli strain HT873X1

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag QCG45_RS20935 Protein ID WP_000347273.1
Coordinates 4267408..4267872 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QCG45_RS20940 Protein ID WP_001307405.1
Coordinates 4267872..4268207 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG45_RS20910 (4263584) 4263584..4264141 - 558 Protein_4067 amidohydrolase family protein -
QCG45_RS20915 (4264137) 4264137..4264508 - 372 Protein_4068 PTS sugar transporter subunit IIC -
QCG45_RS20920 (4264519) 4264519..4264992 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
QCG45_RS20925 (4265015) 4265015..4266295 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
QCG45_RS20930 (4266544) 4266544..4267353 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QCG45_RS20935 (4267408) 4267408..4267872 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QCG45_RS20940 (4267872) 4267872..4268207 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QCG45_RS20945 (4268356) 4268356..4269927 - 1572 WP_001273753.1 galactarate dehydratase -
QCG45_RS20950 (4270302) 4270302..4271636 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
QCG45_RS20955 (4271652) 4271652..4272422 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4267408..4279082 11674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T276743 WP_000347273.1 NZ_CP122318:c4267872-4267408 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT276743 WP_001307405.1 NZ_CP122318:c4268207-4267872 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References