295986

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 606261..607060 Replicon chromosome
Accession NZ_OW968124
Organism Escherichia coli isolate 10

Toxin (Protein)


Gene name yhaV Uniprot ID A0A0A6SPA6
Locus tag LQ159_RS02950 Protein ID WP_000347275.1
Coordinates 606261..606725 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag LQ159_RS02955 Protein ID WP_001307405.1
Coordinates 606725..607060 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ159_RS02920 (601262) 601262..601696 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
LQ159_RS02925 (601714) 601714..602592 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
LQ159_RS02930 (602582) 602582..603361 - 780 WP_000406209.1 PTS N-acetylgalactosamine transporter subunit IIC -
LQ159_RS02935 (603372) 603372..603845 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
LQ159_RS02940 (603868) 603868..605148 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
LQ159_RS02945 (605397) 605397..606206 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
LQ159_RS02950 (606261) 606261..606725 - 465 WP_000347275.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
LQ159_RS02955 (606725) 606725..607060 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
LQ159_RS02960 (607209) 607209..608780 - 1572 WP_001273752.1 galactarate dehydratase -
LQ159_RS02965 (609155) 609155..610489 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
LQ159_RS02970 (610505) 610505..611275 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 606261..617935 11674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17820.29 Da        Isoelectric Point: 9.8492

>T295986 WP_000347275.1 NZ_OW968124:c606725-606261 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKVPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT295986 WP_001307405.1 NZ_OW968124:c607060-606725 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6SPA6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References