92363

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3638688..3639487 Replicon chromosome
Accession NZ_CP025903
Organism Escherichia coli strain 300709

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag CXV43_RS18070 Protein ID WP_000347273.1
Coordinates 3639023..3639487 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag CXV43_RS18065 Protein ID WP_001307405.1
Coordinates 3638688..3639023 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CXV43_RS18050 3634473..3635243 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
CXV43_RS18055 3635259..3636593 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
CXV43_RS18060 3636968..3638539 + 1572 WP_001414016.1 galactarate dehydratase -
CXV43_RS18065 3638688..3639023 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
CXV43_RS18070 3639023..3639487 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
CXV43_RS18075 3639542..3640351 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
CXV43_RS18080 3640600..3641880 + 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
CXV43_RS18085 3641903..3642376 + 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
CXV43_RS18090 3642387..3643166 + 780 WP_000406209.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
CXV43_RS18095 3643156..3644034 + 879 WP_126125428.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
CXV43_RS18100 3644052..3644486 + 435 WP_000948824.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3627801..3639487 11686


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T92363 WP_000347273.1 NZ_CP025903:3639023-3639487 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T92363 NZ_CP025903:3639023-3639487 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT92363 WP_001307405.1 NZ_CP025903:3638688-3639023 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT92363 NZ_CP025903:3638688-3639023 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References