277960

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 642899..643698 Replicon chromosome
Accession NZ_CP122823
Organism Escherichia coli strain ETEC1732

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag QDX01_RS03115 Protein ID WP_000347273.1
Coordinates 642899..643363 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QDX01_RS03120 Protein ID WP_001307405.1
Coordinates 643363..643698 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX01_RS03085 (637900) 637900..638334 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QDX01_RS03090 (638352) 638352..639230 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QDX01_RS03095 (639220) 639220..639999 - 780 WP_282835138.1 PTS N-acetylgalactosamine transporter subunit IIC -
QDX01_RS03100 (640010) 640010..640483 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
QDX01_RS03105 (640506) 640506..641786 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
QDX01_RS03110 (642035) 642035..642844 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QDX01_RS03115 (642899) 642899..643363 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QDX01_RS03120 (643363) 643363..643698 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QDX01_RS03125 (643847) 643847..645418 - 1572 WP_001273753.1 galactarate dehydratase -
QDX01_RS03130 (645793) 645793..647127 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
QDX01_RS03135 (647143) 647143..647913 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 642899..654572 11673


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T277960 WP_000347273.1 NZ_CP122823:c643363-642899 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT277960 WP_001307405.1 NZ_CP122823:c643698-643363 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References