186782

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2866593..2867392 Replicon chromosome
Accession NZ_CP068155
Organism Escherichia coli strain FDAARGOS_1077

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag I6I34_RS14990 Protein ID WP_000347273.1
Coordinates 2866593..2867057 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag I6I34_RS14995 Protein ID WP_001307405.1
Coordinates 2867057..2867392 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I34_RS14960 2861594..2862028 - 435 WP_000948842.1 PTS sugar transporter subunit IIA -
I6I34_RS14965 2862046..2862924 - 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
I6I34_RS14970 2862914..2863693 - 780 WP_000406208.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
I6I34_RS14975 2863704..2864177 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
I6I34_RS14980 2864200..2865480 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
I6I34_RS14985 2865729..2866538 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
I6I34_RS14990 2866593..2867057 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
I6I34_RS14995 2867057..2867392 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
I6I34_RS15000 2867541..2869112 - 1572 WP_001273790.1 galactarate dehydratase -
I6I34_RS15005 2869487..2870821 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
I6I34_RS15010 2870837..2871607 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2866593..2878154 11561


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T186782 WP_000347273.1 NZ_CP068155:c2867057-2866593 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T186782 NZ_CP089772:1962305-1962553 [Mycobacterium tuberculosis]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATAAGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT186782 WP_001307405.1 NZ_CP068155:c2867392-2867057 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT186782 NZ_CP089772:1962093-1962305 [Mycobacterium tuberculosis]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References