27323

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3667688..3668487 Replicon chromosome
Accession NC_017633
Organism Escherichia coli ETEC H10407

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag ETEC_RS18465 Protein ID WP_000347273.1
Coordinates 3668023..3668487 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag ETEC_RS18460 Protein ID WP_001307405.1
Coordinates 3667688..3668023 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ETEC_RS18440 3663473..3664243 - 771 WP_001058208.1 2-dehydro-3-deoxyglucarate aldolase -
ETEC_RS18445 3664259..3665593 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
ETEC_RS18455 3665968..3667539 + 1572 WP_001273753.1 galactarate dehydratase -
ETEC_RS18460 3667688..3668023 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
ETEC_RS18465 3668023..3668487 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
ETEC_RS18470 3668542..3669351 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
ETEC_RS18475 3669600..3670880 + 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
ETEC_RS18480 3670903..3671376 + 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
ETEC_RS18485 3671387..3672166 + 780 WP_000406209.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
ETEC_RS18490 3672156..3673034 + 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
ETEC_RS18495 3673052..3673486 + 435 WP_000948842.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3658540..3668487 9947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T27323 WP_000347273.1 NC_017633:3668023-3668487 [Escherichia coli ETEC H10407]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T27323 NC_017633:3668023-3668487 [Escherichia coli ETEC H10407]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT27323 WP_001307405.1 NC_017633:3667688-3668023 [Escherichia coli ETEC H10407]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT27323 NC_017633:3667688-3668023 [Escherichia coli ETEC H10407]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References