53279

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3418470..3419269 Replicon chromosome
Accession NZ_CP011061
Organism Escherichia coli str. Sanji

Toxin (Protein)


Gene name yhaV Uniprot ID A0A0A6SPA6
Locus tag Y979_RS16795 Protein ID WP_000347275.1
Coordinates 3418805..3419269 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag Y979_RS16790 Protein ID WP_001307405.1
Coordinates 3418470..3418805 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Y979_RS16775 3414255..3415025 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
Y979_RS16780 3415041..3416375 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
Y979_RS16785 3416750..3418321 + 1572 WP_001273752.1 galactarate dehydratase -
Y979_RS16790 3418470..3418805 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
Y979_RS16795 3418805..3419269 + 465 WP_000347275.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
Y979_RS16800 3419324..3420133 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
Y979_RS16805 3420382..3421662 + 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
Y979_RS16810 3421685..3422158 + 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
Y979_RS16815 3422169..3422948 + 780 WP_000406209.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
Y979_RS16820 3422938..3423816 + 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
Y979_RS16825 3423834..3424268 + 435 WP_000948824.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3409322..3419269 9947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17820.29 Da        Isoelectric Point: 9.8492

>T53279 WP_000347275.1 NZ_CP011061:3418805-3419269 [Escherichia coli str. Sanji]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKVPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T53279 NZ_CP011061:3418805-3419269 [Escherichia coli str. Sanji]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGTTCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT53279 WP_001307405.1 NZ_CP011061:3418470-3418805 [Escherichia coli str. Sanji]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT53279 NZ_CP011061:3418470-3418805 [Escherichia coli str. Sanji]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6SPA6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References