137930

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3744858..3745657 Replicon chromosome
Accession NZ_CP043213
Organism Escherichia coli O16:H48 strain CV601gfp

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag FYA04_RS18300 Protein ID WP_000347273.1
Coordinates 3745193..3745657 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag FYA04_RS18295 Protein ID WP_001307405.1
Coordinates 3744858..3745193 (+) Length 112 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYA04_RS18280 3740643..3741413 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
FYA04_RS18285 3741429..3742763 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
FYA04_RS18290 3743138..3744709 + 1572 WP_001273753.1 galactarate dehydratase -
FYA04_RS18295 3744858..3745193 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
FYA04_RS18300 3745193..3745657 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
FYA04_RS18305 3745712..3746521 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
FYA04_RS18310 3746770..3748050 + 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
FYA04_RS18315 3748073..3748546 + 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
FYA04_RS18320 3748557..3748928 + 372 Protein_3573 PTS sugar transporter subunit IIC -
FYA04_RS18325 3748924..3749481 + 558 Protein_3574 amidohydrolase family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3735710..3745657 9947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-150)

Antitoxin

(14-110)


Sequences


Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T137930 WP_000347273.1 NZ_CP043213:3745193-3745657 [Escherichia coli O16:H48]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T137930 NZ_CP057136:4600675-4600962 [Citrobacter freundii]
ATGAGTTATACGGTAAAGTTCAGGGAAGATGCGCTGAAAGAATGGCAAAAATTGGATAAAACCATTCAGCAGCAGTTTGC
CAAAGAACTTAAGAAATACGGTGAAAATCCGCATGTCCCCTCCGCGAAGCTCAGGGGAATAAAAGATTGCTATAAAATCC
AACTACGCACTTCAAGGTTCCGTCTTGTTTATCAAGTTATTGACGACACCCTGGTCATCGCTGTCGTTGCTGTCGGTAAA
CGCGAGCGTAGTGAAGTTTATAATCTTGCCAGCGAAAGACTACGTTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT137930 WP_001307405.1 NZ_CP043213:3744858-3745193 [Escherichia coli O16:H48]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT137930 NZ_CP043213:3744858-3745193 [Escherichia coli O16:H48]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB V0SSH7


Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References