Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | prlF-yhaV (relBE)/YhaV-PrlF |
Location | 611442..612241 | Replicon | chromosome |
Accession | NZ_CP086510 | ||
Organism | Escherichia coli strain Ec-050-T0 |
Toxin (Protein)
Gene name | yhaV | Uniprot ID | A0A0A6SPA6 |
Locus tag | LNN50_RS02970 | Protein ID | WP_000347275.1 |
Coordinates | 611442..611906 (-) | Length | 155 a.a. |
Antitoxin (Protein)
Gene name | prlF | Uniprot ID | S1EB98 |
Locus tag | LNN50_RS02975 | Protein ID | WP_001307405.1 |
Coordinates | 611906..612241 (-) | Length | 112 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LNN50_RS02940 (606443) | 606443..606877 | - | 435 | WP_000948824.1 | PTS galactosamine/N-acetylgalactosamine transporter subunit IIA | - |
LNN50_RS02945 (606895) | 606895..607773 | - | 879 | WP_001295548.1 | PTS N-acetylgalactosamine transporter subunit IID | - |
LNN50_RS02950 (607763) | 607763..608542 | - | 780 | WP_000406209.1 | PTS N-acetylgalactosamine transporter subunit IIC | - |
LNN50_RS02955 (608553) | 608553..609026 | - | 474 | WP_001336162.1 | PTS N-acetylgalactosamine transporter subunit IIB | - |
LNN50_RS02960 (609049) | 609049..610329 | - | 1281 | WP_000681920.1 | tagatose-bisphosphate aldolase subunit KbaZ | - |
LNN50_RS02965 (610578) | 610578..611387 | + | 810 | WP_000072187.1 | aga operon transcriptional regulator AgaR | - |
LNN50_RS02970 (611442) | 611442..611906 | - | 465 | WP_000347275.1 | type II toxin-antitoxin system ribonuclease toxin YhaV | Toxin |
LNN50_RS02975 (611906) | 611906..612241 | - | 336 | WP_001307405.1 | type II toxin-antitoxin system antitoxin PrlF | Antitoxin |
LNN50_RS02980 (612390) | 612390..613961 | - | 1572 | WP_001273752.1 | galactarate dehydratase | - |
LNN50_RS02985 (614336) | 614336..615670 | + | 1335 | WP_000599636.1 | galactarate/glucarate/glycerate transporter GarP | - |
LNN50_RS02990 (615686) | 615686..616456 | + | 771 | WP_001058209.1 | 2-dehydro-3-deoxyglucarate aldolase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | - | 611442..623116 | 11674 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 155 a.a. Molecular weight: 17820.29 Da Isoelectric Point: 9.8492
>T223620 WP_000347275.1 NZ_CP086510:c611906-611442 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKVPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKVPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH
Download Length: 465 bp
>T223620 NZ_CP119047:1888192-1888653 [Staphylococcus epidermidis]
ATGGGGTTATATGAAGAAATTTGTATAGATAATGATATGGTAGAAATTAAAGAAACTAACAAACTACCATCTTTCCAATC
GGGATTTTATATGAACGGAACTGTTTATATAAAAAGTGACTTGTCCGAAAAAGAAAAAATAAAAGTTCTCTACGAAGAAC
TGGCACATCATAAACTTACATATGGAAACATCTTAGACCAATCTAAATTCAACAACCGTAAATTTGAAAACTACGCTAGG
CGTCACGGATATGAAGCTGCTCTACCTTTGCGCATTATTGTGGAGGCGCACAACTATGGTGTTAGTAACTTATATGAATT
AGCTGAATATGTTCAATTAAGTGAAGAGTACATAGCAGAAATATTGAAACATTACAAAAATAAATATGGTATTGGAACTC
ACTACGAAGAATACCTAATTACATTTGATCCGTTGAGAGTTTTTAAATATAAAGAAATATAA
ATGGGGTTATATGAAGAAATTTGTATAGATAATGATATGGTAGAAATTAAAGAAACTAACAAACTACCATCTTTCCAATC
GGGATTTTATATGAACGGAACTGTTTATATAAAAAGTGACTTGTCCGAAAAAGAAAAAATAAAAGTTCTCTACGAAGAAC
TGGCACATCATAAACTTACATATGGAAACATCTTAGACCAATCTAAATTCAACAACCGTAAATTTGAAAACTACGCTAGG
CGTCACGGATATGAAGCTGCTCTACCTTTGCGCATTATTGTGGAGGCGCACAACTATGGTGTTAGTAACTTATATGAATT
AGCTGAATATGTTCAATTAAGTGAAGAGTACATAGCAGAAATATTGAAACATTACAAAAATAAATATGGTATTGGAACTC
ACTACGAAGAATACCTAATTACATTTGATCCGTTGAGAGTTTTTAAATATAAAGAAATATAA
Antitoxin
Download Length: 112 a.a. Molecular weight: 12358.94 Da Isoelectric Point: 4.8616
>AT223620 WP_001307405.1 NZ_CP086510:c612241-611906 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE
Download Length: 336 bp
>AT223620 NZ_CP119047:1887851-1888180 [Staphylococcus epidermidis]
ATGAGAACAAATGATGAAATAATCACAATAATTAAAACAACATTAAAAGAACAAAACATGTCACTTAGTGAATTAGCTCG
TCGTGTAGGAATGGCCAAATCTGCTGTATCACGTTACTTGAATTTAACAAGAGAATTTCCGTTAAACCGTGCGGAAGATT
TTGCGAACGCACTCCATATTAGTACAGAGTATTTACTTGGATTTAATGGAAGTGAACAAACAAGACAACAAGACACTATG
GCTGCTCATTTTGACAAAGAGGGTCTAACAGAAGAAGAAATCGAAGAAGTCAATAAGTTTATTGAGTGGGTTAAGAATAG
AGACAAATAA
ATGAGAACAAATGATGAAATAATCACAATAATTAAAACAACATTAAAAGAACAAAACATGTCACTTAGTGAATTAGCTCG
TCGTGTAGGAATGGCCAAATCTGCTGTATCACGTTACTTGAATTTAACAAGAGAATTTCCGTTAAACCGTGCGGAAGATT
TTGCGAACGCACTCCATATTAGTACAGAGTATTTACTTGGATTTAATGGAAGTGAACAAACAAGACAACAAGACACTATG
GCTGCTCATTTTGACAAAGAGGGTCTAACAGAAGAAGAAATCGAAGAAGTCAATAAGTTTATTGAGTGGGTTAAGAATAG
AGACAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0A6SPA6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E0XVC7 |