285412

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3229382..3230181 Replicon chromosome
Accession NZ_LM993812
Organism Escherichia coli strain K-12 substr. HMS174

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag ECHMS174_RS15965 Protein ID WP_000347273.1
Coordinates 3229717..3230181 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag ECHMS174_RS15960 Protein ID WP_001307405.1
Coordinates 3229382..3229717 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECHMS174_RS15945 3225167..3225937 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
ECHMS174_RS15950 3225953..3227287 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
ECHMS174_RS15955 3227662..3229233 + 1572 WP_001273753.1 galactarate dehydratase -
ECHMS174_RS15960 3229382..3229717 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
ECHMS174_RS15965 3229717..3230181 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
ECHMS174_RS15970 3230236..3231045 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
ECHMS174_RS15975 3231294..3232574 + 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
ECHMS174_RS15980 3232597..3233070 + 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
ECHMS174_RS15985 3233081..3233452 + 372 Protein_3047 PTS sugar transporter subunit IIC -
ECHMS174_RS15990 3233448..3234005 + 558 Protein_3048 amidohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3220234..3230181 9947
- inside Genomic island - - 3220234..3241165 20931


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T285412 WP_000347273.1 NZ_LM993812:3229717-3230181 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT285412 WP_001307405.1 NZ_LM993812:3229382-3229717 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References