193110

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 837734..838533 Replicon chromosome
Accession NZ_CP070103
Organism Escherichia coli strain FDAARGOS_1277

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag I6K07_RS03985 Protein ID WP_085004732.1
Coordinates 838069..838533 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag I6K07_RS03980 Protein ID WP_001307405.1
Coordinates 837734..838069 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K07_RS03965 (833519) 833519..834289 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
I6K07_RS03970 (834305) 834305..835639 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
I6K07_RS03975 (836014) 836014..837585 + 1572 WP_001273753.1 galactarate dehydratase -
I6K07_RS03980 (837734) 837734..838069 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
I6K07_RS03985 (838069) 838069..838533 + 465 WP_085004732.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
I6K07_RS03990 (838588) 838588..839397 - 810 WP_085004733.1 aga operon transcriptional regulator AgaR -
I6K07_RS03995 (839646) 839646..840926 + 1281 WP_000681905.1 tagatose-bisphosphate aldolase subunit KbaZ -
I6K07_RS04000 (840949) 840949..841422 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
I6K07_RS04005 (841433) 841433..842212 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
I6K07_RS04010 (842202) 842202..843080 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
I6K07_RS04015 (843098) 843098..843532 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 826964..838533 11569


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17758.09 Da        Isoelectric Point: 9.2160

>T193110 WP_085004732.1 NZ_CP070103:838069-838533 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYHLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

>T193110 NZ_CP092702:c3168523-3168227 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT193110 WP_001307405.1 NZ_CP070103:837734-838069 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT193110 NZ_CP092702:c3168225-3167830 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References