146841

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3874002..3874801 Replicon chromosome
Accession NZ_CP047594
Organism Escherichia coli strain LD27-1

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag GUU88_RS18780 Protein ID WP_000347273.1
Coordinates 3874337..3874801 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag GUU88_RS18775 Protein ID WP_001307405.1
Coordinates 3874002..3874337 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GUU88_RS18760 3869787..3870557 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
GUU88_RS18765 3870573..3871907 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
GUU88_RS18770 3872282..3873853 + 1572 WP_001273753.1 galactarate dehydratase -
GUU88_RS18775 3874002..3874337 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
GUU88_RS18780 3874337..3874801 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
GUU88_RS18785 3874856..3875665 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
GUU88_RS18790 3875914..3877194 + 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
GUU88_RS18795 3877217..3877690 + 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
GUU88_RS18800 3877701..3878072 + 372 Protein_3667 PTS sugar transporter subunit IIC -
GUU88_RS18805 3878068..3878625 + 558 Protein_3668 amidohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3864854..3874801 9947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T146841 WP_000347273.1 NZ_CP047594:3874337-3874801 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T146841 NZ_CP062811:1049695-1050030 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAACTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT146841 WP_001307405.1 NZ_CP047594:3874002-3874337 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT146841 NZ_CP062811:1049447-1049695 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References